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Ami Wada



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    P2.16 - Treatment in the Real World - Support, Survivorship, Systems Research (ID 187)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Treatment in the Real World - Support, Survivorship, Systems Research
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.16-28 - Retrospective Analysis of Patients with Previous Extrathoracic Malignancies After Resection of Non-Small Cell Lung Cancer (ID 2261)

      10:15 - 18:15  |  Presenting Author(s): Ami Wada

      • Abstract

      Background

      The number of patients with previous malignancies has increased because survival time is prolonged in various malignancies. Therefore, opportunities to consider surgical indications for non-small cell lung cancer (NSCLC) patients with previous malignancies are increasing. The aim of the study is to compare the backgrounds and prognosis of NSCLC patients who had the history of previous extrathoracic malignancies with no other cancer history.

      Method

      Our institutional database of patients after curative resection of NSCLC from 2006 to 2013 was reviewed. Patients with synchronous or metachronous multiple lung cancer were excluded. Clinicopathological features of these patients and information about survival and recurrence were collected from the electronic medical record. Overall survival (OS) and recurrence-free probability (RFP) were estimated using the Kaplan-Meier method.

      Result

      In a total of 249 patients, 49 (19.7%) had previous extrathoracic malignancies. The number of previous extrathoracic malignancies was 1 in 44 patients, 2 in 3 patients and 3 in 1 patient. Sixteen patients had colorectal cancers among previous extrathoracic malignancies, 10 patients had gastric cancers and 5 had hematopoietic neoplasms. If patients with previous extrathoracic malignancies were compared to those without, the median age was 69.5 vs. 65.5 (p=0.015), male sex was 71.4% vs. 66.5% (p=0.506), average of Brinkman index was 914.2 vs. 709.7 (p=0.127) and average of serum level of carcinoembryonic antigen was 5.4 ng/mL vs. 7.5 ng/mL (p=0.506). Pathologically, stage 0 and I NSCLC account for 73.5% of patients with previous extrathoracic malignancies and 66.0% of those without it (p=0.311). The 5-year OS was 70.3% vs. 79.1% (p=0.422) and the 5-year RFP was 58.9% vs. 67.7% (p=0.223).

      Conclusion

      Patients with previous extrathoracic malignancies are significantly older than those without previous extrathoracic malignancies. Patients with previous extrathoracic malignancies had relatively earlier stage NSCLC. The OS and RFP also tended to be worse in patients with previous extrathoracic malignancies. Further study is needed to consider surgical indication for NSCLC with previous extrathoracic malignancies.