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Lanting Gao



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    P2.15 - Thymoma/Other Thoracic Malignancies (ID 185)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Thymoma/Other Thoracic Malignancies
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.15-10 - Clinical Significance of Age at Diagnosis Among Patients with Thymic Epithelial Tumor (Now Available) (ID 1340)

      10:15 - 18:15  |  Author(s): Lanting Gao

      • Abstract
      • Slides

      Background

      Thymic epithelial tumors (TET) originate in the thymus and include thymomas and thymic carcinomas. These tumors typically occur in adults with a median age of 50, and rare in children or adolescents. Few studies focusing on the effect of age on TET have been reported to date. Whether different age groups have homogeneous clinical features and survival outcomes remains unexplored. This study aimed to compare clinicopathologic characteristics and survival outcomes in different age groups using the Surveillance, Epidemiology, and End Results (SEER) database.

      Method

      Information of 4431 TET patients was retrieved from the Surveilance, Epidemiology, and End Results (SEER) database. Demographic features, clinicopathologic characteristics and survival outcomes were compared between patients diagnosed at different age groups (0-18, 19-30, 31-40, 41-50, 51-60, 61-70, 71-80, 80+).

      Result

      A total of 4431 patients were analyzed. Median age was 60-year-old. Twenty-eight (0.6%) patients were aged 1-18, 178 (4.0%) were aged 19-30, 381 (8.6%) were aged 31-40, 742 (16.7%) were aged 41-50, 971 (22.0%) were aged 51-60, 1108 (25.0%) were aged 61-70, 736 (16.6%) were aged 71-80 and 287 (6.5%) were aged 81-90. Gender, race, tumor histology and treatments were similar between different age groups. The 0-18 group was associated with a higher risk of distant metastasis. Compared to patients aged above 80, the hazard ratios of cancer specific survival (CSS) for patients aged 0-18, 19-30, 31-40, 41-50, 51-60, 61-70, 71-80 were 1.079, 0.739, 0.614, 0.621, 0.633, 0.673, and 0.861, respectively. Patients in the 31-40, the 41-50, the 51-60 and the 61-70 age groups had significantly better CSS compared with the 0-18 age group or the 71-80 group or the 81-90 group. From the subgroup analysis, we found that the 19-70 group had significant better CSS and overall survival (OS) than the above 70 group (CSS: p=0.000; OS: p=0.000). Multivariate survival analysis adjusted for gender, race, stage and histology showed that age was an independent prognostic factor for CSS.

      Conclusion

      Age is a strong independent prognostic factor for survival in TET. Pediatric TET has a higher risk of distant metastasis and an inferior CSS. For the adults, patients older than 70-year-old were associated with a shorter CSS.

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