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Oz Shapira



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    P2.15 - Thymoma/Other Thoracic Malignancies (ID 185)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Thymoma/Other Thoracic Malignancies
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.15-08 - Multicenter Experience with Complete Surgical Resection of Primary Pulmonary Artery Sarcoma (Now Available) (ID 2006)

      10:15 - 18:15  |  Author(s): Oz Shapira

      • Abstract
      • Slides

      Background

      Pulmonary artery sarcoma is a rare and aggressive malignancy and survival is extremely limited without surgical resection. Treatment options for surgical resection are not standardized. We sought to examine our series of complete resections and clinical outcomes over an 18 year experience.

      Method

      From 1999 to 2017, we evaluated 17 patients (mean age 56 +/- 12. 9 years) with pulmonary artery sarcoma across three institutions. Fourteen (82.7%) underwent complete surgical resection.

      Result

      All 14 patients underwent complete resection of the pulmonary artery sarcoma. Six patients (42.9%) had previously undergone surgical resection and were referred for recurrent disease. Seven patients (50%) underwent neoadjuvant chemotherapy or radiation. Reconstruction of the pulmonary artery trunk was performed with a pulmonary artery allograft, and reconstruction of the right or left main pulmonary artery was performed with a Dacron interposition graft. Additional endarterectomy was performed in two patients with disease extending into the PA branches. Lung resection was performed in five patients (35.8%). Total length of stay was 9.7 +/- 4.6 days including 5.3 +/- 4.2 days in the ICU. Mean survival was 2 +/- 2.8 years. Tumor histology is summarized in table 1.

      Pulmonary artery sarcomas N=17
      Male gender

      14 (82.65%)

      Age at operation (mean ± SD)

      56 ± 12.9
      Operative 14/17 (82.4%)
      Pre-op chemo only 4/14 (23.5%)
      Pre-op XRT only 1/14 (5.9%)
      Chemo & XRT 2/14 (11.8%)
      Recurrent Disease 6/14 (42.9%)
      Lung Resection/Pneumonectomy 5/12
      ICU Length of stay (mean ± SD) 5.3 ± 4.2

      Total length of stay (mean ± SD)
      		9.7 ± 4.6
      Years alive from surgery (mean ± SD) 2 ± 2.8

      Histology/Pathology

      		Cases (n)

      High Grade Sarcoma

      n= 5
      High Grade Angiosarcoma n= 2
      Leiomyosarcoma n= 2
      High Grade Intimal Sarcoma n= 2
      High Grade Spindle Cell Sarcoma n= 1
      Pleomorphic Sarcoma n= 1
      Undifferentiated Sarcoma n= 1
      Conclusion

      Surgical resection of pulmonary artery sarcomas offers improved long-term outcomes compared to non-surgical management. Complete resection and reconstruction is preferred compared to endarterectomy. Prompt and accurate diagnosis is important for optimal management.

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