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Zhi tao Gu
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P2.15 - Thymoma/Other Thoracic Malignancies (ID 185)
- Event: WCLC 2019
- Type: Poster Viewing in the Exhibit Hall
- Track: Thymoma/Other Thoracic Malignancies
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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P2.15-06 - Pretreatment Neutrophil to Lymphocyte Ratio Predicts Survival in Thymic Carcinoma Patients (ID 627)
10:15 - 18:15 | Author(s): Zhi tao Gu
- Abstract
Background
The host inflammatory response plays an important role in carcinogenesis and disease progression. It has been demonstrated that the neutrophil to lymphocyte ratio (NLR), as a marker of the systemic inflammatory response, was associated clinically meaningful outcomes in patients with a variety of cancers. The objective of this study was to evaluate its prognostic value in thymic carcinoma patients.
Method
From February 2003 to January 2018, 516 consecutive patients with pathologically confirmed thymic carcinomas were treated at the Shanghai Chest Hospital. Clinico-pathological data were retrospectively reviewed. Survival analysis, stratified by NLR quartiles, was used to evaluate the predictive value of NLR.
Result
The NLR level cutoff of four quartiles was 1.9, 2.6 and 3.9 in our patients. After adjusting for the factors affecting the survival (sex, age, tumor size, Masaoka-Koga stage, completeness of resection, chemotherapy and radiotherapy), NLR level less than 1.9 (NLR＜25th percentile, n = 108) remained an independent significant predictor of overall survival (hazard ratio = 1.824, 95% confidence interval = 1.088-3.058, p = 0.023, Table 1). Patients with NLR level ＜1.9 has an advantage on 5-year overall survival (p = 0.001, Figure 1) than their counterpart.
Conclusion
NLR level less than 1.9 measured before treatment is an independent marker of prognosis in thymic carcinoma patients. The NLR does have the advantage of being a routine procedure in clinical practice, feasibility and inexpensive.
