Author of

• 31609

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  P2.15 - Thymoma/Other Thoracic Malignancies (ID 185)

  • Event: WCLC 2019
  • Type: Poster Viewing in the Exhibit Hall
  • Track: Thymoma/Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall

  • 31614

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    P2.15-04 - Impact of Prognostic Nutritional Index on Long-Term Outcomes After Surgery for Pulmonary Metastasis from Colorectal Cancer (ID 2013)

    10:15 - 18:15  |  Author(s): Takafusa Yoshioka
    • Abstract
    • Slides

    Background
    

    A prognostic nutritional index (PNI), calculated using serum albumin levels and peripheral lymphocyte counts, has been reported as a predictor of prognosis of various cancers. The aim of this study was to investigate the impact of a PNI on postoperative prognosis of lung resection for pulmonary metastasis from colorectal cancer.

    Method
    

    Retrospective review of patients who underwent curative surgical resection for pulmonary metastasis from colorectal cancer (01/2008-12/2015). Exclusion criteria: missing data. Preoperative serum albumin (Alb) and peripheral lymphocyte counts were measured within 1 month just before the initial lung surgery. We calculated PNI as follows: PNI = serum albumin levels (g/dl) × 10 + total lymphocyte count (per mm3) × 0.005. We used the median value as the optimal cut-off value for PNI (47.5) and divided patients into two groups. We evaluated overall survival using propensity score matching.

    Result
    

    A total of 158 patients underwent 187 lung resections for pulmonary metastasis in this study. One hundred eighteen patients were eligible. Low PNI was significantly associated with older age (P<0.001), wedge resection (P=0.041), open approach (P=0.045) and colon origin (P=0.041). In the non-matched analysis, overall survival was significantly better in high PNI group that low PNI group (77.5% vs 54.0% at 5 years; HR 2.21; 95% CI 1.11-4.39; P=0.024). After propensity score matching accounting for sex, age, surgical procedure, surgical approach and site of origin, there were no significant differences in background between both groups. In the matched analysis, overall survival was significantly better in high PNI group than low PNI group (78.2% vs 43.2% at 5 years; HR 3.46; 95% CI 1.33-8.96; P=0.010).

    

    Conclusion
    

    Preoperative PNI may be a useful biomarker to predict postoperative prognosis of pulmonary metastasis from colorectal cancer.

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