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Marcello Carlo Ambrogi



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    P2.15 - Thymoma/Other Thoracic Malignancies (ID 185)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Thymoma/Other Thoracic Malignancies
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.15-02 - Primary Salivary Gland-Type Lung Tumours, Surgically Treatable Rare Entity Lung Cancer: A Sixteen-Year Experience of a Single Centre (Now Available) (ID 1119)

      10:15 - 18:15  |  Author(s): Marcello Carlo Ambrogi

      • Abstract
      • Slides

      Background

      Primary salivary gland-type lung tumours (PSGT) are uncommon entity, representing 0.09% of overall lung cancer. Due to their rarity, this category of malignancies remain incompletely understood and the role of surgery is poorly known. The primary endpoint of this study was to analyse the impact of surgical treatment on outcome for PSGT lung cancer

      Method

      A retrospectively analysis of patients who underwent a surgical treatment for PSGT tumours between January 2001 and January 2017 in a single centre was conducted. Overall survival (OS), disease free survival (DFS) and medical records (for age, sex, clinical conditions, location, surgical treatment, histopathology and tumour grade) were analysed

      Result

      Out of a total of 30 PSGT lung tumours, 26 patients (15 female, 11 male) with an average age of 58.1±12.7 years underwent surgical resection with curative intent. Four patients were excluded from this study because of metastatic disease (2) or unresectable masses that underwent only palliative endoscopic treatment (2).

      Adenoid cystic carcinoma was diagnosed in 14 patients, mucoepidermoid carcinoma in 10 patients, and epithelial-myoepithelial carcinoma in 2 patients. Fourteen patients (54%) were current/former smoker. Twelve tumours originated from main bronchus/trachea, 14 from lobar/sublobar bronchus. The surgical procedure included lobectomy (n = 9, 34.6 %), sub-lobar resection (n=5, 19.2%), tracheal resection (n = 4, 15.4%), pneumonectomy (n = 3, 11.5%), sleeve lobectomy (n = 4, 15.4%), and carinal resection (n = 1, 3.8%). No operative mortality or major complications were reported; minor complications (e.g. air leaking, arrhythmias) occurred in five patients (19.2%). Mean dimension of tumours was 3.67±3.24 cm. Three patients underwent adjuvant therapies (2 radiotherapy, 1 chemotherapy). Cancer recurred in 11 patients (42.3%): 3 were surgically treated, 3 underwent chemotherapy, 1 radiotherapy and 4 combined radio-chemotherapy. With a median follow-up of 70 months, the overall survival was 68.8 months and the disease free survival was 56.8 months. The 5-year OS and DFS were 92% and 68% respectively. Adenoid cystic carcinoma was the most favourable subtype with a median OS of 90 months. Only three cancer-related dead occurred

      Conclusion

      Surgical resection of primary salivary gland-type lung cancer is an effective treatment even in case of large tumours that required extended resections. The long-term survival and the DFS after surgical resection are encouraging and redo surgical procedure with a curative intent can be performed in case of local recurrences

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