Author of

• 31322

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  P2.11 - Screening and Early Detection (ID 178)

  • Event: WCLC 2019
  • Type: Poster Viewing in the Exhibit Hall
  • Track: Screening and Early Detection
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall

  • 31346

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    P2.11-20 - Risk Factors of Lung Cancer Development in IPF Patients (ID 676)

    10:15 - 18:15  |  Presenting Author(s): Hye Seon Kang
    • Abstract

    Background
    

    Idiopathic pulmonary fibrosis (IPF) is known as a risk factor for lung cancer (LC) by several previous studies, and that the presence of LC shortens survival in patients with IPF. However, the risk factors for the development of LC after the diagnosis of IPF have not been fully evaluated. We investigated the predictive factors for LC by longitudinal cohort analysis.

    Method
    

    This was a retrospective study of a single center interstitial lung disease cohort. Study patients were consecutively enrolled to the cohort between March 2006 and December 2018 at Bucheon St. Mary’s Hospital, The Catholic University of Korea. This cohort study consists of 102 patients with IPF, and the incidence of LC and the outcomes were investigated.

    Result
    

    During the mean follow-up periods of 62.7 months, 27 patients (26%) developed LC. The most frequent cell type was Squamous cell carcinoma, and the proportion of male was higher in IPF-LC group (92.6% vs 70.7%, p=0.021). In univariate cox regression analysis, low forced vital capacity (FVC) <75% (p<0.001), and low diffusion capacity of the lungs for carbon monoxide (DLco) <55% (p<0.001) was associated with LC development. In Cox proportional hazards model, low FVC (hazard ratio [HR]: 5.65; 95% confidence interval [CI]: 1.78-17.84, p=0.003) and low DLco (HR: 27.5; 95% CI: 1.97-386.6, p=0.014) were independent predictive factors for LC in stepwise multivariate analysis.

    Conclusion
    

    Low FVC and Low DLco, which are pulmonary function parameters reflecting their severity of IPF, are suggested as independent risk factors for LC development in IPF patients.