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Shuo Wu



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    EP1.11 - Screening and Early Detection (ID 201)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Screening and Early Detection
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.11-09 - Evaluation of Seven-Autoantibody Panel Test in Early Detection of Lung Cancer in Routine Clinical Practice (Now Available) (ID 1384)

      08:00 - 18:00  |  Author(s): Shuo Wu

      • Abstract
      • Slides

      Background

      There is an increasing incidence of pulmonary nodules due to the promotion and popularization of low-dose computed tomography (LDCT) screening for potential populations with suspected lung cancer. However, high rate of false-positive and concern of radiation-related cancer risk of repeated CT scanning remains major obstacle to its wide application. Here, we aimed to investigate the clinical value of a non-invasive and simple test, named 7 autoantibodies (AABs) assay (P53, PGP9.5, SOX2, GAGE7, GUB4-5, MAGEA1 and CAGE), in distinguishing malignant pulmonary nodules from benign ones in routine clinical practice.

      Method

      152 patients with malignant lung diseases and 151 with benign pulmonary diseases were identified. The serum levels of the 7-AABs were tested by Enzyme-linked Immunosorbent Assay (ELISA). The primary goal was to assess the sensitivity, specificity, false positive rate (FPR) and positive predictive value (PPV) of the 7-AABs panel in detection of lung cancer.

      Result

      The serum levels of AABs (including PGP9.5, GAGE7, GBU4-5 and MAGEA1) in malignant group were significantly higher than that in benign group. The sensitivity and specificity of the 7-AABs panel test were 46.1% and 82.9% in whole group, and 35.3% and 70.0% in cases with pulmonary nodules. Comparing to 7-AABs panel test or LDCT screening plus multiplane reformation (MPR) alone, the combination of 7-AABs panel and LDCT screening+MPR improve the PPV ( 70.6% vs 89.5%; P < 0.001) and reduce the FPR (21.1% vs 30.0% ; P < 0.001) in patients with pulmonary nodules.


      Conclusion

      The 7-AABs panel may be a promising method for early detection of lung cancer. It would be a valuable diagnostic tool to distinguish malignant pulmonary nodules from benign ones.

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