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Masahito Naito



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    P2.09 - Pathology (ID 174)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Pathology
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.09-20 - The Possible Clinical Significances of Infiltration of CD8+ Lymphocytes in Non-Small Cell Lung Cancers (ID 1963)

      10:15 - 18:15  |  Author(s): Masahito Naito

      • Abstract

      Background

      Understanding of the immune contexture of tumor microenvironments might provide knowledge predicting the effect of immunotherapies and prognosis. The amount of CD8+tumor-infiltrating lymphocytes (TILs) seems to be a promising candidate as positive prognostic factor in non-small cell lung cancer (NSCLC). However, few details are understood. Hence, we investigated the prognostic significance of CD8+TILs in NSCLC.

      Method

      Of the NSCLCs surgically resected in our institution between 2011 and 2013, those with more than 10% of their tumor cells growing in a solid pattern were immunohistochemically studied to evaluate the CD8+TILs in both tumor parenchyma and stroma. The number of CD8+TILs in tumor parenchymal elements and the percentages of stromal CD8+TILs compared with the total amount of nucleated cells in stromal elements which means “density” were assessed by a digital pathology scoring software. Data were analyzed with Kaplan-Meier survival analysis and Cox proportional hazards models. The primary endpoint of this study was relapse-free survival (RFS).

      Result

      Eighty-four patients were included in this study. The median age was 69 (range 31-81) years and the majority of patients were men (85%). Histologically, 52 cases were squamous cell carcinomas, 19 adenocarcinomas, 9 pleomorphic carcinoma and 4 other types. In univariate analysis, the density of stromal CD8+TILs was a significant poor prognostic factor (P=0.0053), while the number of intraparenchymal CD8+TILs showed no prognostic significance. In addition, the multivariate analysis also indicated that the density of stromal CD8+TILs was a significant poor prognostic factor (HR, 3.62; 95% CI, 1.37-9.55; P=0.0094).

      Conclusion

      Our data showed that a high density of stromal CD8+TILs might be associated with patient’s shorter RFS. Further studies are needed to verify the presenting findings.