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P2.06 - Mesothelioma (ID 170)
- Event: WCLC 2019
- Type: Poster Viewing in the Exhibit Hall
- Track: Mesothelioma
- Presentations: 1
- Now Available
- Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
P2.06-22 - Is Laboratory Prognostic Index a Valuable Prognostic Index for Malignant Pleural Mesothelioma? (Now Available) (ID 1445)
10:15 - 18:15 | Author(s): Ozlem Ercelep
Prognostic significance of Laboratory Prognostic Index (LPI) was demonstrated in non-small cell lung cancer before. We aimed to assess the prognostic value of LPI in patients with malignant pleural mesothelioma (MPM).Method
Records of MPM patients were examined retrospectively for serum laboratory results at diagnosis along with demographical and clinicopathological features. LPI is consisted of white blood cell count (>10000/mm3), albumin (<3.5 g/dL), lactate dehydrogenase (>248 U/L), alkalene phosphatase (>120 U/L) and calcium (>10.5 mg/dL) levels; and it is graded according to the number of abnormal parameters: 0 (none), 1 (one) and 2 (two or more). Kaplan-Meier method and stratified log-rank test were used in univariate analysis and a Cox regression model was conducted to determine independent predictors of overall survival (OS).Result
Sixty-one patients were included in the study. Median age at diagnosis was 59 (51-66) years. 45 deaths (73.8%) have occurred at the time of final analysis and median OS was 19.5 months. One-year survival rates for patients with LPI 0, 1 and 2, were 82%, 61% and 59%; 2-year survival rates were 75%, 47% and 24%, respectively. Median OS of patients with LPI 0, 1 and 2 were 36.5, 21.7 and 15.6 months, respectively (p=0.007). Age, ECOG performance status, histology, hemoglobin level and LPI were found to effect OS significantly or to have a trend (p<0.1). In multivariate analysis, LPI (p=0.033) and ECOG performance status (p<0.001) were the independent prognostic factors.Conclusion
The LPI may be a valuable prognostic factor in mesothelioma as well. Larger studies are needed to confirm this result.
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