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Yangyang Wang



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    P2.05 - Interventional Diagnostic/Pulmonology (ID 168)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Interventional Diagnostics/Pulmonology
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.05-14 - Safety and Risk Factors of CT-Guided Percutaneous Transthoracic Needle Re-Biopsy for NSCLC (ID 779)

      10:15 - 18:15  |  Author(s): Yangyang Wang

      • Abstract
      • Slides

      Background

      Re-biopsy of NSCLC after systemic therapy to identify molecular resistance mechanism is very important. CT-guided needle lung re-biopsy has proven feasible. This study aimed to discover the safety of computed tomography (CT)-guided percutaneous transthoracic needle re-biopsy for patients with NSCLC, and its risk factors.

      Method

      This was a retrospective, single-institution study. 113 patients who diagnosed as IIIB/IV NSCLC and treated with EGFR-TKIs/chemotherapy from January 2016 to February 2018 in our hospital. Compare the differences incidence of complications between first biopsy and re-biopsy by computed tomography (CT)-guided percutaneous transthoracic needle, and analysis the clinical factors affecting main complications in re-biopsy.

      Result

      Success rate of re-biopsy was 88.5% (100/113). The number of patients with complications in first biopsy was 25 (23.9%), and it’s 37 (34.5%) in re-biopsy (Table). The main complications were hemorrhage and pneumothorax. Hemorrhage rate in re-biopsy, male was 18.5% (10/54), and female was 3.4% (2/59). Re-biopsy needle size 17G (Angiotech 17G coaxial trocar together with Biopince 18G automatic biopsy needle) was 5.7% (5/87), and needle size 18G (18G Angiotech soft biopsy needle) was 26.9% (7/26). The mean frequency of intraoperative needle adjustment with and without hemorrhage was 3.3±1.8 vs 2.2±1.6. The mean distance (cm) of pleura-to-target in with and without hemorrhage was 3.7±1.5 vs 2.3±1.9. High rate of pneumothorax for needle through interlobular septal puncture in re-biopsy, 62.5% (5/8). CT-guided percutaneous transthoracic needle re-biopsy of NSCLC was showed in Figure.

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      Conclusion

      First biopsy and re-biopsy complications were similar. Both of hemorrhage and pneumothorax were acceptable. CT-guided percutaneous transthoracic needle re-biopsy of NSCLC showed safe and feasible.

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