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Yojiro Yutaka

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    P2.05 - Interventional Diagnostic/Pulmonology (ID 168)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Interventional Diagnostics/Pulmonology
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.05-08 - Diagnostic Yield of EBUS-TBNA in Evaluation of PD-L1 Expression for Advanced Non-Small Cell Lung Cancer (ID 1825)

      10:15 - 18:15  |  Author(s): Yojiro Yutaka

      • Abstract
      • Slides


      Endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) plays a major role in mediastinal staging for advanced non-small cell lung cancer, but the amount of obtained tissue is limited compared to surgical biopsy. The purpose of this study was to assess the diagnostic yield of EBUS-TBNA in evaluating PD-L1 expression in positive mediastinal lymph nodes.


      A retrospective chart review was performed on our prospectively maintained database to identify patients who underwent EBUS-TBNA to evaluate PD-L1 expression in mediastinal lymph nodes associated with advanced non-small cell lung cancer between April 2017 and March 2019. Relevant factors were extracted and compared between those whose PD-L1 expression was able to be evaluated and those whose PD-L1 expression was not.


      Thirty-six patients were identified. The PD-L1 expression was able to be evaluated in 30 (83%) of 36 patients. There were tendencies for a greater diameter (p=0.19) and higher standard uptake value (SUV) in positron emission tomography (p=0.22) of biopsied lymph nodes, and a greater number of biopsies (p=0.28) in those whose PD-L1 expression was be able to be evaluated. Among 30 patients with evaluable PD-1 expression, the degree was high expression (tumor proportion score (TPS) ≧ 50%) in 7 patients (23%), low expression (TPS 1-49%) in 10 patients (33%), and no expression (TPS < 1%) in 13 patients (44%).



      Evaluation of PD-L1 expression was feasible in more than 80% patients undergoing EBUS-TBNA for positive mediastinal lymph nodes associated with advanced non-small cell lung cancer. EBUS-TBNA appeared to play an important role in evaluating PD-L1 expression. A larger lymph node, and a lymph node with higher SUV, and a greater number of punctures appeared favorable in evaluation of PD-L1 expression.

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