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Ismail Sarbay



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    P1.17 - Treatment of Early Stage/Localized Disease (ID 188)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Treatment of Early Stage/Localized Disease
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/08/2019, 09:45 - 18:00, Exhibit Hall
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      P1.17-42 - The Importance of Lymphatic and Vascular Invasion in Stage 1 Non-Small Cell Lung Cancer and Definition of a Totally Curable Tumors (ID 2681)

      09:45 - 18:00  |  Author(s): Ismail Sarbay

      • Abstract

      Background

      A number of non-anatomic prognostic factors have been reported for resected non-small cell lung carcinoma. Certain histopathologic properties of the tumor such as lymphatic and vascular invasion could help to predict the patients with excellent survival.

      Method

      A retrospective study was conducted on 550 surgically resected stage 1 non-small cell lung carcinomas, and the following prognostic factors were evaluated in univariate analysis: age, gender, size of tumor, histologic type of tumor, grade of differentiation, lymphatic invasion, vascular invasion, and perineural invasion. The mean follow-up time was 69 months(range;10 to 181 months).

      Result

      Lymphatic vessel invasion, perineural invasion, blood vessel invasion, size of tumor(i.e.,T1a, T1b, T1c) of the tumor were found to be significant prognostic factors (p=0.001, p=0.006, p<0.001 and p=0.029 respectively). According to multivariate analyses, two factors were selected as prognostic indicators: (1) lymphatic invasion (p=0.027;OR:2.27;95%confidence interval:1.097-4.7), (2) vessel invasion (p =0.013;OR:2.021;95%confidence interval:1.16-3.53). By combining these factors we identified a poor and excellent prognostic subgroups of patients with stage I disease. The patients with 1A1 disease without lymphatic or blood vessel invasion had 100% of 5-year survival

      Conclusion

      Our study showed that lymphatic vessel and blood vessel invasion of the tumor could be prognostic factors, along with anatomical determinants. The patients with stage 1A1 tumors who had no lymphatic or blood vessel invasion seem to be totally cured by surgical resection.

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    P2.03 - Biology (ID 162)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Biology
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.03-56 - Polymorphism ICAM-1 and Beta-3 Integrin Are Associated with the Development of Non-Small Cell Lung Cancer and the Prognostic Role of ICAM-1 (Now Available) (ID 2615)

      10:15 - 18:15  |  Author(s): Ismail Sarbay

      • Abstract
      • Slides

      Background

      Lung cancer is widespread cancer in the worldwide. Non-small cell lung cancer (NSCLC) accounts for 80-85% of all lung cancers. ICAM-1 and β3 integrin have been have been found to be associated with the angiogenesis, tumor growth and metastasis in various tumor types. Our primary aim in this study was to explore gene polymorphisms in ICAM-1 and β3 integrin molecular pathway in NSCLC patients and to clarify whether these values are effective on the etiopathogenesis and prognosis of the disease.

      Method

      Sixty-nine patients with operable (T1-4N0-1M0) NSCLC patients and 120 healthy individuals between January 2012 and June 2018 were included in the study. The tumor samples were taken after resected specimen. Blood samples of the patients were also collected before surgical resection. ICAM-1 and β3 integrin gene polymorphisms were determined by using PCR-RFLP techniques. Also serum ICAM levels were determined by ELISA method. The stages of the tumor were constructed according to 8th staging system.

      Result

      There was no statistically significant difference between patient with NSCLC and healthy control groups with regard to β3 Integrin Leu33Pro gene polymorphism(p=0.182). However, in patients with NSCLC, AG genotype frequency and G allele carriers of ICAM K469E variant were found to be higher than the control group and the difference was statistically significant(OR:2,710 95%CI:1,364-5,376; p=0.005). It has been determined that having a G allele increased approximately 2,95 fold the risk of disease and also carrying of AGTC combined genotype increased(OR:2,95 95%CI:1,366-6,373;p=0.049). When patients were evaluated according to tumor stage, serum levels of ICAM-1 gene in early tumor stage was found to be significantly higher than in advanced tumor stage (p=0,013). No significant difference was found between the range of histopathological subtypes and serum ICAM levels (p>0,05). Also, no statistically significant association was found between serum ICAM levels and angiolymphatic invasion (p=0.101, perineural invasion(p=0.054), lymph node metastasis (p=0.585).

      Conclusion

      ICAM-1 as an intercellular adhesion molecule seems to play an important role in lung carcinogenesis and it might play a role in the invasiveness of the tumor. However, β-3 integrin was not found to be associated with lung cancer development. The role of ICAM-1 in the genesis of lung cancer as well as immune mechanism should be further investigated.

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