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Leona Yamamoto



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    P2.03 - Biology (ID 162)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Biology
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.03-52 - Correlation Between Inflammatory Markers and Oncological Outcomes in Surgically Resected Non-Small Cell Lung Cancer (Now Available) (ID 2917)

      10:15 - 18:15  |  Author(s): Leona Yamamoto

      • Abstract
      • Slides

      Background

      Various systemic inflammatory factors have been recognized as predictive markers of oncological outcomes in human malignant diseases. Recently, combined scores of inflammatory factors of preoperative peripheral blood have been reported as more sensitive and powerful markers for predicting oncological and survival outcomes in several solid organ malignancies. In the present study, we evaluate the predictive value of various inflammatory parameters for oncologic outcomes in non-small cell lung cancer patients.

      Method

      We retrospectively reviewed patients with non-small cell lung cancer undergoing complete resection with pathological nodal evaluation between January 2016 and February 2019 in our department. We assessed the correlation between inflammatory factors including combined parameters from preoperative peripheral blood and pathologic findings expressing oncological invasiveness such as pT3/T4, solid/micropapillary subtype in adenocarcinoma, pleural invasion, lymph node metastasis, and any sort of M factors. The evaluated inflammation-related scores are follows; C-reactive protein (CRP), neutrophils, lymphocytes, albumin, platelets, lactate dehydrogenase (LDH), alkaline phosphatase (ALP), lymphocyte-CRP ratio (LCR), CRP-albumin ratio (CAR), platelet-albumin ratio (PLR), neutrophil-lymphocyte ratio (NLR), lymphocyte-LDH ratio (LLR), albumin-ALP ratio (AAR) and LDH-albumin ratio (LAR). Preoperative carcinoembryonic antigen (CEA) level and maximum standard uptake value (SUV max) of FDG-PET on primary lesions were also evaluated as known predictive markers of oncological outcome in non-small cell lung cancer.

      Result

      A total of 306 patients were enrolled in this study. The following data are clinicopathological findings of this cohort; age: 69.5±9.9, gender: male 212, female 94, histology: squamous 64, adeno 230, adenosquamous 4, other 8, solid/micropapillary in adeno 52, pT3/T4 35, positive pleural invasion 75, positive lymph node metastasis 56, positive M factor 1 (dissemination). Results of significant predictive markers are follows (p<0.05, a stronger marker is placed on left side); CRP, CEA, NLR, SUV for pT3/T4, CRP, albumin, LDH, SUV for positive pleural invasion, CRP, CEA, LAR, albumin for pN positive, respectively. No predictive markers were identified regarding histological subtype in adenocarcinoma.

      Conclusion

      In non-small cell lung cancer patients, combined inflammatory scores derived from preoperative peripheral blood could predict limited oncological outcomes. Known predictive markers such as CRP, CEA and SUV max on PET-CT reflected the outcomes more strongly.

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