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Di Lu



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    EP1.15 - Thymoma/Other Thoracic Malignancies (ID 205)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Thymoma/Other Thoracic Malignancies
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.15-18 - An 18-Year Single-Center Experience on 76 Giant Mediastinal Tumor Resections (Now Available) (ID 862)

      08:00 - 18:00  |  Author(s): Di Lu

      • Abstract
      • Slides

      Background

      Giant mediastinal tumors are often case reported in sparse and can be difficult for surgical removal. The purpose of this study was to make a comprehensive review of the relevant clinical data in our center, aiming to upgrade our current understanding of the disease.

      Method

      A retrospective review of medical record was conducted at our single institution from 2001 to 2019. The preoperative, postoperative characteristics and survival data were retrieved. The patients under 16 years old were excluded. The descriptive statistical analysis and Kaplan-Meier analysis were R-3.5.0.

      Result

      A total of 76 patients with mediastinal tumors over 10cm underwent surgery in this period were summarised: the median age is 44; the maximum tumor diameter ranges from 10cm to 35cm; the surgical approaches include median sternotomy, lateral thoracotomy, and with or completed by minimally invasive procedure; the blood loss in surgery ranges from 100ml to 3000ml; average postoperative the hospitalization is 30 days. The average overall survival is 39 months.

      Conclusion

      With careful preoperative evaluation, our results indicate that surgical management of giant mediastinal tumor is safe and recommended. Patients with a benign or less aggressive malignant tumor who received surgery have a favorable outcome in terms of long-term survival.

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    P1.03 - Biology (ID 161)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Biology
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 09:45 - 18:00, Exhibit Hall
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      P1.03-49 - Systematic Dysregulation of Cell Cycle by lncRNAs in Lung Adenocarcinoma (Now Available) (ID 867)

      09:45 - 18:00  |  Author(s): Di Lu

      • Abstract
      • Slides

      Background


      LncRNAs are associated with tumor progression, immune escape, and survival, but how do lncRNAs systematically change the tumor microenvironment and what biological function is dysregulated are less reported.

      Method

      In our previous report, lung adenocarcinoma (LUAD) RNA sequencing data were downloaded from The Cancer Genome Atlas (TCGA). Differential analysis and lncRNA- protein-coding-gene co-expression analysis was performed; the signal pathways of expressed genes are clustered and enriched.

      Result

      AC109642.1, RP11-582J16.4, RP11-378A13.1, TBX5-AS1, AC090616.2, AC079630.4, SFTA1P, FENDRR, RP11-736K20.4, RP11-389C8.2 and MIR22HG are low expressed in cancer tissue compared to tumor-matched normal tissue, while the EEF1A1P6, MBNL1-AS1, ADAMTS9-AS1, LINC00987, LINC01197, EP300-AS1, PCAT19, OR7E47P, AC093110.3, RP11-366L5.1, LINC00968, CTD-2562J17.6, RP11-203P23.2, AF131215.2, RP11-434D9, LINC00702, RP11-1024P17.1 and MAGI2-AS3 are high expressed. These lncRNAs regulated coding proteins are clustered into seven categories and systematically mediated cell cycle dysfunction in LUAD.

      wclc 2019.png

      Figure 1 The network of lncRNAs regulated protein-coding genes. The red triangles indicate low expressed lncRNAs in tumor tissue; the green rectangular indicate high expressed lncRNAs in tumor tissue and the blue ovals indicate regulated coding genes.

      Conclusion

      This is the first time to reveal that the dysregulated lncRNAs systemically affect the cell cycle in LUAD tissue. The dynamic change of lncRNAs and the associated protein-coding genes network could give us a better epigenetic understanding and future direction of targeting uncontrollable LUAD growth.

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