Author of

• 30601

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  P2.01 - Advanced NSCLC (ID 159)

  • Event: WCLC 2019
  • Type: Poster Viewing in the Exhibit Hall
  • Track: Advanced NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall

  • 30694

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    P2.01-85 - Schwann Cells Are Overexpressed and Inversely Correlated with Survival of Non-Small Cell Lung Cancer Patients (ID 497)

    10:15 - 18:15  |  Presenting Author(s): Yan Zhou
    • Abstract

    Background
    

    The lungs are densely innervated by the peripheral nervous system (PNS). We have recently reported the presence of schwann cells(SCs), the principal glial cells of the PNS, in the murine and human lungs and the mechanisms by which tumor–neuroglia interaction affect lung cancer growth and metastasis(Cancer Research. 2018;78(20):5927-39). Nevertheless, the clinical epidemiological characters of the innervation of lung cancer has not been intensively investigated.This study aimed to complement this vacancy by determining the prevalence of SCs expression in NSCLC and analyzing its associations with clinical pathologic parameters and outcome.

    Method
    

    Totally, 141 operated patients at stage I-III NSCLC were enrolled. Formalin-fixed and paraffin-embedded (FFPE) tumour sections were reviewed and stained with glia-specific antibodies S100b, GFAP and P75NTR. The correlations between expression of SCs and clinical pathologic features, overall survival (OS) and recurrence free survival(RFS) were analyzed.

    Result
    

    No significant relationship were found between SCs expression and patients’gender, age, smoking history, subtype or EGFR status. Interestingly, SCs expression was markedly increased in cancer tissues compared with in adjacent tissues. Furthermore, SCs were significantly overexpressed in tumors of stage II-III than in stage I(P<0.01). Kaplan-Meier curve analysis revealed that high expression of SCs was negatively associated with longer RFS (P<0.001) and OS(P<0.001).5 year-RFS were 18.8%(High) and 51.8%(Low) respectively.

    Conclusion
    

    High expression of SCs is negatively correlated with tumor stage and survival, indicating its potential diagnostic and therapeutic value for operated NSCLC patients.