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Emanuela Olmetto
Author of
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P2.01 - Advanced NSCLC (ID 159)
- Event: WCLC 2019
- Type: Poster Viewing in the Exhibit Hall
- Track: Advanced NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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P2.01-74 - Clinical-Pathological Features and Outcome of Patients with Oral Metastases from Lung Cancer: A Multicenter Retrospective Study (ID 2701)
10:15 - 18:15 | Author(s): Emanuela Olmetto
- Abstract
Background
Oral metastases are a rare event, accounting to less than 1% of all oral malignancies, sometimes being the first manifestation of a wide-spread disease. Regardless of the site of the primary tumor, patients with oral metastases have a poor prognosis, with a reported median overall survival (mOS) of 6 months. Lung cancer, particularly small cell lung cancer (SCLC) and poorly differentiated carcinoma, represents the main source of oral metastases, even if large datasets still lack. We conducted a multicenter retrospective study investigating incidence, clinical-pathological features and outcome of patients with oral metastases from lung cancer.
Between January 2014 and December 2018 we collected data from all consecutive patients diagnosed with lung cancer in four oncological Italian centers. Clinical-pathological features of those patients with oral metastases involving jaw or/and soft tissues were described.
Among 4,082 consecutive lung cancer patients, the incidence of oral cavity metastases was 0.15% (6 out of 4,082 patients,). Patients were more frequently male (5 out of 6, 83%), current or former smokers (5 out of 6, 83%), with a median age at diagnosis of 61 years (range 53-69) [table 1]. Four different histotypes of lung cancer were detected. Five patients (83%) were stage IV ab initio, with synchronous histologically confirmed oral metastases. All these patients had distant metastases other than in the oral cavity (median of 5 different metastatic sites). The mOS since the diagnosis of oral metastases was 67 days (range 36-166).
Table 1. Patient characteristics
Gender
Age (years)
Smoke
Histotype
N° metastatic sites
Site of oral lesion
Time between stage IV diagnosis and oral lesion occurrence
Local radiotherapy
Median OS from oral lesion occurrence (days)
M
69
Current
Poorly differentiated
4
Jaw
Syncronous
Yes
57
M
61
Current
Sarcomatoid
5
Jaw
Syncronous
Yes
107
M
61
Former
Adenocarcinoma
3
Gum
11 months
Yes
77
M
53
Former
Poorly differentiated
4
Gum
Syncronous
No
44
M
59
Current
SCLC
5
Gum
Syncronous
No
36
F
66
Unknown
Squamous (mut ex 19 EGFR)
5
Gum
Syncronous
No
166
To our knowledge, this is the largest study assessing the incidence of oral metastases in lung cancer patients. Oral involvement, usually diagnosed at an advanced stage, seems to be associated with a very poor prognosis, with a mOS of about 2 months. Further confirmatory datasets are warranted.