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Emanuela Olmetto



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    P2.01 - Advanced NSCLC (ID 159)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Advanced NSCLC
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.01-74 - Clinical-Pathological Features and Outcome of Patients with Oral Metastases from Lung Cancer: A Multicenter Retrospective Study (ID 2701)

      10:15 - 18:15  |  Author(s): Emanuela Olmetto

      • Abstract
      • Slides

      Background

      Oral metastases are a rare event, accounting to less than 1% of all oral malignancies, sometimes being the first manifestation of a wide-spread disease. Regardless of the site of the primary tumor, patients with oral metastases have a poor prognosis, with a reported median overall survival (mOS) of 6 months. Lung cancer, particularly small cell lung cancer (SCLC) and poorly differentiated carcinoma, represents the main source of oral metastases, even if large datasets still lack. We conducted a multicenter retrospective study investigating incidence, clinical-pathological features and outcome of patients with oral metastases from lung cancer.

      Method

      Between January 2014 and December 2018 we collected data from all consecutive patients diagnosed with lung cancer in four oncological Italian centers. Clinical-pathological features of those patients with oral metastases involving jaw or/and soft tissues were described.

      Result

      Among 4,082 consecutive lung cancer patients, the incidence of oral cavity metastases was 0.15% (6 out of 4,082 patients,). Patients were more frequently male (5 out of 6, 83%), current or former smokers (5 out of 6, 83%), with a median age at diagnosis of 61 years (range 53-69) [table 1]. Four different histotypes of lung cancer were detected. Five patients (83%) were stage IV ab initio, with synchronous histologically confirmed oral metastases. All these patients had distant metastases other than in the oral cavity (median of 5 different metastatic sites). The mOS since the diagnosis of oral metastases was 67 days (range 36-166).

      Table 1. Patient characteristics

      Gender

      Age (years)

      Smoke

      Histotype

      N° metastatic sites

      Site of oral lesion

      Time between stage IV diagnosis and oral lesion occurrence

      Local radiotherapy

      Median OS from oral lesion occurrence (days)

      M

      69

      Current

      Poorly differentiated

      4

      Jaw

      Syncronous

      Yes

      57

      M

      61

      Current

      Sarcomatoid

      5

      Jaw

      Syncronous

      Yes

      107

      M

      61

      Former

      Adenocarcinoma

      3

      Gum

      11 months

      Yes

      77

      M

      53

      Former

      Poorly differentiated

      4

      Gum

      Syncronous

      No

      44

      M

      59

      Current

      SCLC

      5

      Gum

      Syncronous

      No

      36

      F

      66

      Unknown

      Squamous (mut ex 19 EGFR)

      5

      Gum

      Syncronous

      No

      166

      Conclusion

      To our knowledge, this is the largest study assessing the incidence of oral metastases in lung cancer patients. Oral involvement, usually diagnosed at an advanced stage, seems to be associated with a very poor prognosis, with a mOS of about 2 months. Further confirmatory datasets are warranted.

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