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Violeta Grammatikou



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    P2.01 - Advanced NSCLC (ID 159)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Advanced NSCLC
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.01-54 - Real-World PD-L1 Testing Patterns for Patients with Advanced Non-Small Cell Lung Cancer in Greece (ID 2138)

      10:15 - 18:15  |  Author(s): Violeta Grammatikou

      • Abstract
      • Slides

      Background

      Programmed Cell Death Protein-1 (PD-1) and Programmed Death Ligand-1 (PD-L1) inhibitors are important immunotherapy targets for non-small cell lung cancer (NSCLC). This study sought to describe PD-L1 testing for patients with NSCLC in Greece.

      Method

      This non-interventional study is based on Sotiria Lung Cancer Registry in Greece recording patients with histologically or cytologically confirmed stage IIIB/IV NSCLC diagnosis, who initiated systemic treatment between August, 15th 2016 and August, 14th 2018.

      Result

      A total of 472 patients were included in the registry. Demographic and first-line treatment information are presented in Table 1, along with the respective comparison between patients tested and not tested for PD-L1. Patients with ECOG PS 0-1 are more likely to be tested for PD-L1 status. Among patients tested for PD-L1, Dako 22C3 was the most commonly used testing assay (87.8%).

      The number of patients tested for PD-L1 increased between the two consecutive time periods (from August, 15th 2016 to August, 14th 2018; Table 2).

      table 1.jpg

      table 2.jpg

      Conclusion

      The percentage of newly diagnosed patients with advanced NSCLC in Greece tested for PD-L1 status doubled in a year (August, 15th 2016 – August, 14th 2018). Among those tested, 67% were tested prior to first-line treatment initiation and 26% of those tested had PD-L1 TPS ≥50%.

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