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Ralf Joachim Rieker

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    EP1.01 - Advanced NSCLC (ID 150)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Advanced NSCLC
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.01-49 - Histology-Depended Pattern of Patho-Histological Response After Induction Therapy in Locally Advanced Non-Small Cell Lung Cancer (Now Available) (ID 2251)

      08:00 - 18:00  |  Author(s): Ralf Joachim Rieker

      • Abstract
      • Slides


      Pathological response after induction therapy (IT) is expected to be associated with favorable outcome in locally advanced non-small cell lung cancer (NSCLC). The pathologic response pattern remains unpredictable. Aim of this retrospective study was to analyze the patho-histologic response according to tumor histology, in order to identify the potential correlation and prognostic impact.


      In 57 patients with locally advanced NSCLC the patho-histologic response to IT were assessed and compared for adenocarcinoma vs. squamous cell lung cancer after curative lung resection. The prognostic differences were estimated by Kaplan-Meier method and compared using log-rank test.


      The IT included chemo-radiation with 50.4Gy (range 45-56.4 Gy) combined with platin-based chemotherapy in 54 patients (94.7%) or only platin-based chemotherapy in 3 patients (4.3%). Perioperative morbidity and 30-days-mortality was 36% and 3.5%, respectively. Complete resection was achieved in 93% patients. Significantly improved long-term survival and recurrence-free survival were associated with <15% viable squamous cells and with <60% viable adenocarcinoma cells (long rank 0.013 and 0.012, 0.04 and 0.05, respectively). The median long-term survival for <15% viable squamous cells was 35.2 months, recurrence-free survival was not achieved; for <60% viable adenocarcinoma cells the median long-term and recurrence-free survival were 87.9 and 35.9 months, respectively.


      The patho-histologic response pattern to IT is correlated to tumor histology and has potential implication on pathologic assessment. Distinct prognostic impact can be further reflected in the clinical practice and multimodal treatment strategies.

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