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Kyongmin Sarah Beck
EP1.01 - Advanced NSCLC (ID 150)
- Event: WCLC 2019
- Type: E-Poster Viewing in the Exhibit Hall
- Track: Advanced NSCLC
- Presentations: 1
- Now Available
- Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
EP1.01-48 - Invasive Mucinous Adenocarcinoma of the Lung: Serial CT Findings, Clinical Features, and Treatment Outcomes (Now Available) (ID 1203)
08:00 - 18:00 | Presenting Author(s): Kyongmin Sarah Beck
Invasive mucinous adenocarcinoma of the lung is a rare and distinct subtype of adenocarcinoma, previously described as bronchoalveolar carcinoma (BAC). In our daily practice, we have sometimes encountered spontaneous regression without treatment in patients with invasive mucinous adenocarcinomas, but serial CT findings of this cancer have not been described in the literature. We performed an analysis to describe the serial chest CT findings, clinical features, and treatment outcomes of patients with invasive mucinous adenocarcinoma of the lung.
From January 2013 to June 2018, 49 cases of pathology-confirmed invasive mucinous adenocarcinoma of the lung were identified. Initial chest CT and follow-up CTs were available for 48 patients (23 men and 25 women; median age, 69.5 years; range, 26-82 years). Median follow-up period was 19.0 months (range, 0-110 months). Serial CT scans were reviewed, with emphasis on changes over time and in relation to medical or surgical treatment. Patients were classified as either nodule/mass type or consolidation type according to the initial CT. Clinical, radiological, and treatment outcomes were compared between nodule/mass and consolidation types by adopting the χ2 test, Mann-Whitney U test, and Kaplan-Meier analysis with log-rank tests.Result
There were 33 nodule/mass type and 15 consolidation type at initial CT scan. Of 15 consolidation type, 9 patients showed combined GGO. Consolidation type presented with significantly larger lesion size (p<0.001), higher stage (p<0.001), and multifocality (p=0.001) on initial CT and showed spontaneous regression without treatment during follow-up (p<0.001) compared to the nodule/mass type. Six patients died during follow-up, and they were all from the consolidation group (p<0.001). 33 patients underwent surgery and 11 patients received chemotherapy. Patients with the consolidation type showed reduced progression-free survival (PFS) (mean 9.5 months) compared with those with the nodule/mass type (mean 63.9 months) (p<0.001).Conclusion
Invasive mucinous adenocarcinomas of the lung appearing as consolidation on initial CT are larger and multifocal, have higher stage, higher mortality, and reduced PFS, and can show spontaneous regression.
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