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Tae Yun Park



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    EP1.01 - Advanced NSCLC (ID 150)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Advanced NSCLC
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.01-42 - Is Serum Lymphocyte Count Predictive Biomarker to Identify Lung Cancer Patients Who May Benefit from an Immunotherapy? (Now Available) (ID 2039)

      08:00 - 18:00  |  Author(s): Tae Yun Park

      • Abstract
      • Slides

      Background

      Programmed death ligand 1 (PD-L1) expression is not truly reflected response of immunotherapy. Thus, tumor mutational burden is new biomarker for predict response of immunotherapy. However, sufficient quantity or quality tumor samples must be obtained, so this is limitation. Therefore, we investigated whether high serum lymphocyte is predictive biomarker for immunotherapy response regardless of PD-L1 immunohistochemistry stain among lung cancer patients.

      Method

      We retrospectively analyzed the medical charts of lung cancer patients who treated with immunotherapy (pembrolizumab, nivoluamb, ipilimumab, atezolizumab) at Seoul National University Hospital between April 2016 and March 2019. We evaluated correlation the serum lymphocyte count (SLC) with the progression free survival (PFS) using multivariable linear regression. SLC was evaluated when patients

      Result

      Total 236 patients treated with immunotherapy for lung cancer. SLC at baseline was not significantly associated with progression free survival (Coeff = -0.00, p = 0.478) after adjustment age, sex, ECOG status, histology and PD L-1 expression status. The 1-year progression free survival rate was 14.8% and patients who survived over 1 year were not revealed difference of SLC compared with those who didn’t survive over 1 year. When we divided two group according lymphocyte count as 5000/uL, among patients who were over 5000/uL of lymphocyte related with increased progression probability (hazard ratio for disease progression, 1.68; 95 % CI, 1.03 to 2.77; P=0.04).

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      Conclusion

      In this study, we revealed that increased serum lymphocyte count over 5000/uL at baseline when immunotherapy start is associated with decreased progression free survival among lung cancer patients who treated with immunotherapy.

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