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Hongxuan Li



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    EP1.01 - Advanced NSCLC (ID 150)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Advanced NSCLC
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.01-34 - A Retrospective Study of the Pattern of Lymph Node Metastasis in Superior Sulcus Non-Small-Cell Lung Cancers (Now Available) (ID 1742)

      08:00 - 18:00  |  Presenting Author(s): Hongxuan Li

      • Abstract
      • Slides

      Background

      By comparing the probability of lymph node metastasis between superior sulcus non–small-cell lung cancers (SS NSCLC) and non-SS NSCLC located in the pulmonary apex, we hope to find out whether there is a unique pattern of lymph node metastasis in SS NSCLC.

      Method

      During 2008-2014, a retrospective study was performed on NSCLC patients with lesions located in the pulmonary apex. Patients with lesions invading the peripheral tissue structure were enrolled in the SS NSCLC group, while those without lesions invading the peripheral structure were enrolled in the non-SS NSCLC group. A total of 65 patients in the SS NSCLC group received surgery, and all patients in the non-SS NSCLC group received surgery. According to postoperative pathology and enhanced CT before treatment, the location and number of lymph node metastasis were determined. The chi-square test was used to statistically analyze the difference in the probability of N1, N2 and distant metastasis (DM) between the two groups.

      Result

      Compared with the non-SS NSCLC group, the T staging of SS NSCLC group was advanced, but the rate of N1 lymph node metastasis was similar. However, the N2 lymph node metastasis rate of the SS NSCLC was significantly lower than that of the non-SS NSCLC, which was 25.3% and 39.8% respectively (P=0.048). Distant metastasis rates were similar at lower levels in both groups,which was 9.3% and 6.4% respectively (P=0.471).

      Table Basic information and results
      SS NSCLC N0n-SS NSCLC P value Chi-square
      Gender male 67 65
      female 8 28
      Median age 61(37-87) 62(42-82)
      ad 27 67
      Pathology squ 32 16
      others 16 10
      T stage T3+T4 75(100%) 3(3.2%) 0.000* 156.328
      N1 25(33.3%) 33(35.8%) 0.771 0.085
      N2 19(25.3%) 37(39.8%) 0.048* 3.902
      DM 7(9.3%) 6(6.4%) 0.471 0.519

      Ad:adenocarcinoma squ: squamous carcinoma DM:distant metastasis

      * P<0.05. There were significant differences between the two groups.

      Conclusion

      Although T staging was very late in SS NSCLC, the N2 lymph node metastasis rate and distant metastasis rate did not increase correspondingly. Therefore, enhanced local treatment, such as neoadjuvant concurrent chemoradiotherapy combined with surgery, may lead to better survival benefits.

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