Author of

• 30292

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  EP1.01 - Advanced NSCLC (ID 150)

  • Event: WCLC 2019
  • Type: E-Poster Viewing in the Exhibit Hall
  • Track: Advanced NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall

  • 30320

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    EP1.01-24 - Lung Adenocarcinoma: Mutational Profile in Ever Smokers and Non-Smokers Patients (ID 2847)

    08:00 - 18:00  |  Author(s): Catarina Marques
    • Abstract
    • Slides

    Background
    

    Lung cancer occurring in never-smokers had become a distinct entity. This study aims to evaluate the mutational profile in ever smokers and non-smokers patients with pulmonary adenocarcinoma.

    Method
    

    Retrospective analysis (Oct-2016 to Aug-2017) of patients diagnosed with pulmonary adenocarcinoma in our pulmonology department.

    Next generation sequencing (NGS) was used to identify different mutations and translocations. Pathological variants of genes and variants of uncertain clinical significance were included.

    Result
    

    60 patients were enrolled in this study: 18 (30%) non-smokers and 42 (70%) ever smokers.

    In 72.2% of non-smokers and 57.1% of ever smokers were identified at least one mutation. Despite this, ever smokers had an overall higher frequency of mutations (72.6% vs 27.4%) because many patients had concomitant mutations.

    Although not statistically significant, ever smokers had more mutations that are variants of uncertain clinical significance (40% vs 23.5%; p=0,227)

    Table 1. Frequency of mutations

    ___

    Non-smoker

    Ever smokers

    Mutated gene	Pathological variants (n)	Variants of uncertain clinical significance (n)	Pathological variants (n)	Variants of uncertain clinical significance (n)
    KRAS	3	0	18	0
    EGFR	5	0	4	5
    ERBB4	0	0	0	1
    MET	0	1	0	3
    PTEN	0	0	1	1
    HER2	1	2	0	7
    PI3KCA	0	1	1	1
    BRAF	0	0	1	0
    ROS	1	0	1	0
    ALK	3	0	1	0
    Total	13	4	27	18

    Conclusion
    

    Although not statistically significant, smokers and non-smokers appear to have a different mutational profile. Smokers have a higher rate of concomitant mutations, although some of them are variants of uncertain clinical significance. NGS will help to increase knowledge about the mutational profile in these patients.

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