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Sehyun Kwak

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    EP1.01 - Advanced NSCLC (ID 150)

    • Event: WCLC 2019
    • Type: E-Poster Viewing in the Exhibit Hall
    • Track: Advanced NSCLC
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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      EP1.01-11 - Prognosis of Lung Cancer in Patients with Interstitial Lung Disease; Comparison with NSIP and IPF (Now Available) (ID 1307)

      08:00 - 18:00  |  Presenting Author(s): Sehyun Kwak

      • Abstract
      • Slides


      Lung cancer is the leading cause of death in worldwide. Some reports revealed that lung cancer with interstitial lung disease (ILD) is associated with poor prognosis. However, the prognosis of lung cancer according to the subtype of ILD is unclear. We analyzed the outcome of lung cancer according to CT findings of ILD.


      Among the non-small cell lung cancer (NSCLC) patients who visited Severance Hospital, Seoul, Korea from July 2005 to October 2018, patients with idiopathic pulmonary fibrosis (IPF) or non-specific interstitial pneumonia (NSIP) in chest CT image were enrolled in this study. Patients were divided into three groups according to CT findings; (1) definite + possible IPF, (2) intermediate, and (3) definite NISP + possible NSIP. All patients were diagnosed lung cancer NSCLC on biopsy. The characteristics of study population and prognosis of each group were examined


      A total of 151 patients were investigated in this study. Female was 4.6% and mean age was 70.2 years. 84 patients were definite + possible IPF group, 42 patients were intermediate, and 25 patients were definite NISP + possible NSIP group. The proportion of smokers who smoked once was significantly higher in definite + possible IPF group (p=0.006). Age, FVC, FEV1 and lung cancer stage were not different between the three groups. Median overall survival were 27.0 months in NSIP group, 15.3 months in intermediate group, and 9.5 months in IPF group (p=0.04). Additionally, 25% of patients in definite + possible IPF group experienced acute exacerbation.


      CT findings of ILD in lung cancer patients could be helpful in predicting prognosis. Furthermore, acute exacerbation is more common in IPF patients. Therefore, careful attention should be paid to the treatment of lung cancer in patients with IPF pattern.

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