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Yoshiharu Ohno
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EP1.01 - Advanced NSCLC (ID 150)
- Event: WCLC 2019
- Type: E-Poster Viewing in the Exhibit Hall
- Track: Advanced NSCLC
- Presentations: 1
- Now Available
- Moderators:
- Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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EP1.01-50 - Quantitative Assessment of Subsegmental Bronchi on Thin-Section CT for Pulmonary Lymphangitis Carcinomatosa (Now Available) (ID 2290)
08:00 - 18:00 | Author(s): Yoshiharu Ohno
- Abstract
Background
CT is the main modality to measure the of the tumor and/or metastasis of solid malignancies to evaluate the change over time due to conservative therapy, especially in chemotherapy. However, the change of lymphangitis carcinomatosa which appears at advanced stage could be evaluated quantitatively, only. The purpose of this study was to evaluate the availability of CT to quantify the lymphangitis carcinomatosa of lung cancer.
Method
Fifteen consecutive patients (12 males, three females; 51-76 y.o.) with pulmonary lung cancer who were diagnosed as lung cancer with lymphangitis carcinomatosa by CT were enrolled retrospectively. Each patient’s lung cancer was diagnosed by using bronchoscope or CT guided biopsy. All patients underwent CT examination before and after the chemotherapy. All CT studies were performed by using MDCT machine (Aquilion Prime or Aquilion Precision; Canon Medical Systems, Otawara, Japan). All CT examinations were performed with 80 or 160-detector row CT scanner with contrast media. CT images were reconstructed with 1mm slice, 1mm interval, 512 x 512 matrix. The long axis diameters of primary tumors were measured on CT before and after the therapy. The wall area of the sub-segmental bronchus affected by lymphangitis carcinomatosa was defined by Synapse Vincent (Fujifilm Medical; Tokyo, Japan) before and after the therapy. The correlation coefficient of tumor reduction rates between the primary tumor diameter and wall area of the affected sub-segmental bronchus was statistically assessed. P value less than 0.05 was considered as significant in statistical analyses.
Result
The correlation coefficient of tumor reduction rates between the primary tumor diameter and wall area of the affected sub-segmental bronchus was 0.533 (p = 0.041).
Conclusion
The positive correlation of tumor reduction rates was significant between the primary tumor diameter and wall area of the affected sub-segmental bronchus. The measurement of wall area of affected sub-segmental bronchus on thin-slice CT has the availability to evaluate the quantitative change of lymphangitis carcinomatosa of lung cancer patients.
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EP1.11 - Screening and Early Detection (ID 201)
- Event: WCLC 2019
- Type: E-Poster Viewing in the Exhibit Hall
- Track: Screening and Early Detection
- Presentations: 1
- Now Available
- Moderators:
- Coordinates: 9/08/2019, 08:00 - 18:00, Exhibit Hall
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EP1.11-08 - Ultra-High-Resolution CT to Project the Detailed Components in Nodules; Fat Components in Pulmonary Hamartomas (Now Available) (ID 2332)
08:00 - 18:00 | Author(s): Yoshiharu Ohno
- Abstract
Background
The purpose of this study was to evaluate the utility of the detailed matrix of ultra-high-resolution CT (UHRCT) to detect the detailed attenuation heterogeneity in pulmonary hamartoma which contains fat component.
Method
Seven consecutive patients (three males, four females; 48-73 y.o.) with pulmonary hamartoma who underwent UHRCT were enrolled retrospectively. Each patient’s hamartoma was diagnosed by using bronchoscope, surgical therapy or follow up study. All CT studies were performed by using ultra-high-resolution CT machine (Aquilion Precision; Canon Medical Systems, Otawara, Japan). All CT examinations were performed with 160-detector row CT scanner; 120kVp, auto-mAs, 1792 channels, collimation 0.25 mm x 160 rows, 1024 matrix. Conventional high-resolution CT (HRCT) images were reconstructed with 1mm slice, 1mm interval, 512 x 512 matrix. Ultra-high- resolution CT (UHRCT) images were reconstructed with 0.25 mm slice, 0.25 mm interval, 1024 x 1024 matrix. The CT densities of each hamartoma were measured by placing ROI at the longest diameter of the nodule on CT image. The lowest densities in the nodule were statistically compared between on HRCT and UHRCT by using paired t-test. P value less than 0.05 was considered to be significant.
Result
The average minimum densities of hamartomas on HRCT and UHRCT were -39.1 and -65.0, respectively (p = 0.092).
Conclusion
The lowest densities of hamartomas were lower on UHRCT than on HRCT, not significantly. The UHRCT’s smaller voxel may reveal the detailed heterogeneity in the nodule to detect fat component of hamartoma.
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OA10 - Sophisticated TNM Staging System for Lung Cancer (ID 136)
- Event: WCLC 2019
- Type: Oral Session
- Track: Staging
- Presentations: 1
- Now Available
- Moderators:Ke-Neng Chen, Pedro Lopez De Castro
- Coordinates: 9/09/2019, 14:00 - 15:30, Toronto (1985)
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OA10.05 - Which Is Better for TNM Stage Assessment Among Whole-Body MRI and PET/MRI at 1.5 Tesla and 3 Tesla and FDG-PET/CT in Non-Small Cell Lung Cancer? (Now Available) (ID 910)
14:00 - 15:30 | Presenting Author(s): Yoshiharu Ohno
- Abstract
- Presentation
Background
Accurate tumor staging is essential for choosing the appropriate treatment strategy for non-small cell lung cancer (NSCLC) patients. In 1990s, positron emission tomography (PET) or PET combined with CT (PET/CT) using 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) were suggested as useful for TNM stag evaluation in NSCLC patients in routine clinical practice. Since 2007, whole-body magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) at 1.5T or 3T systems and PET/MRI have been continuously testing in this setting. Moreover, PET fused with MRI (PET/MRI) with FDG has been suggested as a new tool for TNM stage and postoperative recurrence evaluations since 2015. However, all PET/MRI has been generated by MRI at 3T MR system and not tested that at 1.5T system. No one reported direct comparisons for TNM staging capability among whole-body MRI and PET/MRI at 1.5T and 3T systems and PET/CT in NSCLC patients. We hypothesize that whole-body MRI and PET/MRI at 1.5T and 3T MR systems have better potential for TNM stage assessment than whole-body FDG-PET/CT in NSCLC patients. The purpose of this study was to prospectively and directly compare TNM stage classification capability among whole-body MRI and PET/MRI at 1.5 and 3T MR systems and PET/CT in NSCLC patients.
Method
104 consecutive pathologically diagnosed NSCLC patients (62 men, 42 women; mean age 71 years) prospectively underwent whole-body MRI at 1.5T and 3T systems, integrated PET/CT, and surgical, pathological and/ or follow-up examinations. Final diagnoses of T, N and M factors and clinical stage in each patient were determined according to all examination results. Then, each factor and clinical stage were visually assessed on both whole-body MRIs, PET/MRIs and PET/CT with contrast-enhanced brain MRI. Kappa statistics were used to determine agreements for assessment of all factors and clinical stage with final diagnoses, and McNemar’s test was used to compare each diagnostic accuracy among all methods.
Result
Conclusion
On each factor and clinical stage assessments, agreements between all methods and final diagnosis were substantial or almost perfect (0.60<κ<0.98). Diagnostic accuracies of N factor and clinical stage on whole-body MRI as well as PET/MRI at both field strengths were significantly higher than those of PET/CT (p<0.05).
Whole-body MRIs and PET/MRIs at 1.5T and 3T systems have significantly better potential for N factor and clinical stage assessments than PET/CT in NSCLC patients.
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