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OA10 - Sophisticated TNM Staging System for Lung Cancer (ID 136)
- Event: WCLC 2019
- Type: Oral Session
- Track: Staging
- Presentations: 1
- Now Available
- Moderators:Ke-Neng Chen, Pedro Lopez De Castro
- Coordinates: 9/09/2019, 14:00 - 15:30, Toronto (1985)
OA10.03 - Macroscore: A Prognostic Model for Supplementing the TNM Stage in Resectable Non–Small Cell Lung Cancer (Now Available) (ID 630)
14:00 - 15:30 | Presenting Author(s): Rui Mao
We aim to establish a prognostic model based on the macrophage status to supplement the TNM stage and increase the predictive accuracy for the prognosis of NSCLC patients.Method
The macrophage infiltration at the center of the tumor and its invasive margins in stage I to IIIA NSCLC patients (n=368) was evaluated, and a Macroscore model was constructed (Low/Intermediate/High). The relationship between the Macroscore and the clinical outcome was analyzed and validated by 2 additional cohorts.Result
The Macroscore was significantly associated with disease-free survival rates and overall survival rates at each TNM stage (all p < .0001). The TNM stage could not, however, determine survival rates in patients with the same Macroscore (figure 1). In patients experienced a 5-year event, the Macroscore is usually in high level (26.0%-53.1%). Patients have not experienced a 5-year event usually have a low Macroscore (71.7%-84.8%), regardless of the TNM stage (figure 2). Furthermore, the Macroscore could improve the area under the curve values for the DFS and OS; the values of DFS increased from 0.651 for the TNM system model to 0.822 for the TNM stage plus Macroscore model.
The Macroscore provides an accurate prediction of the clinical outcome in resectable NSCLC tumors, and it complements the prognostic value of the TNM stage.
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