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Juan Barros-Dios



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    OA09 - Lung Cancer: A Preventable Disease? (ID 134)

    • Event: WCLC 2019
    • Type: Oral Session
    • Track: Prevention and Tobacco Control
    • Presentations: 1
    • Now Available
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      OA09.06 - Residential Radon, Smoking and Lung Cancer Risk. A Case-Control Study in a Radon Prone Area (Now Available) (ID 1260)

      11:00 - 12:30  |  Author(s): Juan Barros-Dios

      • Abstract
      • Presentation
      • Slides

      Background

      Residential radon is the second risk factor of lung cancer following tobacco consumption and the main one in never smokers, according to the WHO and USEPA statements. The joint effect of tobacco and radon exposure has been little studied and residential radon is a neglected risk factor of this disease. We aim to show lung cancer risk for different combinations of tobacco consumption and residential radon exposure on the risk of lung cancer.

      Method

      Pooling case-control study in a radon-prone area where we have combined individual information from 5 different multicentric case-control studies. 11 Spanish hospitals from 4 different regions have taken part. All case-control studies had a similar methodology, including incident, primary, and histologically confirmed lung cancer cases and controls attending hospital for trivial surgery not related with tobacco consumption. Cases and controls were older than 30 and controls were matched with cases using a frequency-based sampling using age and gender distribution of cases. Detailed information was obtained regarding tobacco consumption, and a radon device was placed in the participants’ dwelling for at least three months. We calculated lung cancer risk for each category of tobacco consumption and radon exposure taking as a reference those participants never smokers and with an indoor radon concentration below 50 Bq/m3. All Odds Ratios are accompanied by their 95% confidence intervals.

      Result

      We included 1691 cases and 1698 controls with a similar distribution on age and gender. Heavy smokers exposed to low radon concentrations (< 50Bq/m3) posed a risk of lung cancer of 12.6, compared to 31.3 for heavy smokers exposed to indoor radon higher than 200 Bq/m3. The different odds ratios and confidence intervals for each category of exposure appear in the Table.

      table.jpg

      Conclusion

      There is an interaction between indoor radon and tobacco. Risk of lung cancer increases significantly when both risk factors are present.

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    P2.10 - Prevention and Tobacco Control (ID 176)

    • Event: WCLC 2019
    • Type: Poster Viewing in the Exhibit Hall
    • Track: Prevention and Tobacco Control
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/09/2019, 10:15 - 18:15, Exhibit Hall
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      P2.10-05 - Indoor Radon and Lung Cancer Risk. A Pooling Study on the Second Risk Factor for Lung Cancer (Now Available) (ID 277)

      10:15 - 18:15  |  Author(s): Juan Barros-Dios

      • Abstract
      • Slides

      Background

      Residential radon is the second risk factor of lung cancer following tobacco consumption, according to WHO (World Health Organization) and United States EPA statements. It is recognized as the first cause of lung cancer in never-smokers by both organizations. Nevertheless, case-control studies performed in radon prone areas are still scarce and with limited sample sizes. We aim to know the relationship between residential radon and lung cancer risk in a study performed in a radon-prone area, and where inhabitants live for a long time in the same dwelling.

      Method

      We have pooled results from 5 different case-control studies performed in the same geographical area to assess the relationship between indoor radon and lung cancer. One of these studies was focused specifically in never smokers and other in Small Cell Lung Cancer. All cases and controls were older than 30 and cases had a confirmed diagnosis of lung cancer. Controls were selected for attending hospital for trivial surgery. Controls were selected through a frequency-based sampling based on age and gender distribution of cases. The information and questionnaires collected was the same in all studies, with special focus on tobacco consumption. Radon devices of an alpha track type were placed at the participants’ homes for at least three months. Odds Ratios of lung cancer due to radon exposure have been calculated adjusted by age, gender, and tobacco consumption.

      Result

      We included 1691 cases and 1698 controls. Median age was 63 and 67, respectively, and females comprised 33% of both cases and controls. Adenocarcinoma was the most frequent histology (43%) and participants lived a median of 30 years in the same dwelling. The table show the risk of lung cancer due to radon exposure.

      table.jpg

      Conclusion

      Residential radon is a relevant risk factor for lung cancer, even below concentrations established as safe by USEPA and WHO.

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