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PL04 - Food for Thought in the Management of Thoracic Malignancies (ID 91)
- Event: WCLC 2019
- Type: Plenary Session
- Track: Advanced NSCLC
- Presentations: 1
- Now Available
PL04.02 - What Does Survivorship Mean in the World of Immunotherapy (Physical and Financial)? (Now Available) (ID 3596)
16:15 - 17:00 | Presenting Author(s): Michelle Turner
With improvements in diagnostic, therapeutic, and supportive therapies, the number of cancer survivors
continues growing with over 20 million cancer survivors worldwide and an estimated 2/3 of adults with
a cancer diagnosis who are anticipated to be alive in 5 years1. Due to this increase in survivors, major
medical societies such as American Society of Clinical Oncology (ASCO), Institute of Medicine (IOM), and
the Society for Immunotherapy of Cancer’s (SITC) have highlighted the need for strategies to improve
the ongoing care of survivors and survivorship plans.2
The 4 basic tenets of a survivorship plan are surveillance, prevention, intervention and coordination.
Surveillance is aimed at monitoring for recurrence, second cancers, and long term toxicities, prevention
of these sequelae if possible, intervention if they are found, and lastly coordination between hospital
and community‐based doctors is essential for this plan to be effective.3 These needs are typically
communicated to the patient’s general practitioner (GP)/primary care physician (PCP) by a “care plan”
that outlines the patient’s oncology treatment course, potential long‐term toxicity, the
frequency of follow up visits, scans and links to community resources.
New cancer therapies such as immunotherapy has resulted in significantly improved overall survivals in
many advanced cancers, including those that had formerly been considered refractory.6,7,8 However, the
short‐, intermediate‐, and long‐term complications of these therapeutic agents are still being identified.
Immune‐mediated events, for example, can occur immediately after therapy initiation or even up to two
years post treatment as a consequence of overstimulation of the immune system leading to
autoimmunity with the potential for permanent or long‐term sequelae.4,5
3. Denlinger, CS et. Al. Survivorship: Introduction and Definition. J Natl Compr Canc Netw. 2014 Jan; 12(1): 34–45.
4. Sheela S, Kim ES, Mileham KF. Moving away (finally) from doublet therapy in lung cancer: immunotherapy and KEYNOTE‐189J Thorac Dis. 2018 Sep;10(9):5186‐5189.
5. Weber JS, Hodi FS, Wolchok JD, et al. Safety Profile of Nivolumab Monotherapy: A Pooled Analysis of Patients With Advanced Melanoma. J Clin Oncol 2017; 35:785.
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