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Mary Salvatore



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    MS10 - Lung Cancer Screening, Opportunistic Evaluation of Findings (ID 73)

    • Event: WCLC 2019
    • Type: Mini Symposium
    • Track: Screening and Early Detection
    • Presentations: 1
    • Now Available
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      MS10.06 - Interstitial Lung Diseases (Now Available) (ID 3497)

      15:45 - 17:15  |  Presenting Author(s): Mary Salvatore

      • Abstract
      • Presentation
      • Slides

      Abstract

      Lung Cancer in patients with Lung Fibrosis

      Mary M. Salvatore MD, MBA

      Patients with a history of smoking are enriched population for studying pulmonary fibrosis and as patients are living longer with fibrosis, they are becoming an enriched population for studying lung cancer (1). Usual interstitial Pneumonitis is the most frequent pattern of pulmonary fibrosis in the United States. There are 48,000 new patients with IPF each year in the US and 40,000 die (2). Ozawa found that the cumulative incidence of lung cancer is 3.3%, 15.4%, and 54.7% at 1, 5, and 10 years of IPF (3). Adenocarcinoma is most common lung cancer in the general population. Kawasaki found that of 53 patients with IPF and lung cancer, there was no predominant histology. There are similarities between lung cancer and fibrosis, which include invasion of normal tissue, lack of monoclonality, mutation of tumor suppressor genes and epithelial mesenchymal transformation (4). The tumor microenvironment often causes cancers in fibrosis to have shorter doubling times. The survival of patients with lung fibrosis and cancer is poor with up to 93% 5-year mortality (5). Screening for lung cancer in patients with fibrosis is different from screening in non-fibrotic patients because of the potential rapid growth of some cancers.

      Lung cancer occurring in a patient with fibrosis are different from lung cancer occurring in a patient with emphysema. The patients are often not candidates for surgery. If they have surgery, it should be as limited as possible to decrease the risk of exacerbation (6). Chemotherapy increase risk of an exacerbation as does immunotherapy (7). Radiation has an increased risk of exacerbation as well; perhaps proton therapy may have better outcomes (8). In summary as patients are living longer with fibrosis the incidence of lung cancer is increasing however the treatments for early cancer in patients with lung cancer increase the risk of fibrosis exacerbation and further study is necessary in this area to make recommendations for best practices.

      References:

      1. Salvatore M, Henschke CI, Yip R, Jacobi A, Eber C, Padilla M, Knoll A, Yankelevitz D. JOURNAL CLUB: Evidence of Interstitial Lung Disease on Low-Dose Chest CT Images: Prevalence, Patterns, and Progression. AJR Am J Roentgenol 2016 Mar; 206(3):487-94.

      2. G. Raghu, S.Y. Chen, Q. Hou, W.S. Yeh, H.R. Collard, Incidence and prevalence of idiopathic pulmonary fibrosis in US adults 18-64 years old, Eur. Respir. J.48 (1) (2016).

      3. Ozawa Y, Suda T, Naito T, Enomoto N, Hashimoto D, Fujisawa T, Nakamura Y, Inui N, Nakamura H, Chida K.: Cumulative incidence of and predictive factors for lung cancer in IPF. Respirol. Carlt. Vic., 14 (5) (2009), pp. 723-728.

      4. H. Kawasaki, K. Nagai, T. Yokose, J. Yoshida, M. Nishimura, K. Takahashi Clinicopathological characteristics of surgically resected lung cancer associated with idiopathic pulmonary fibrosis. J. Surg. Oncol., 76 (1) (2001), pp. 53-57.

      5. Teixeira MR, Heim S. Cytogenetic analysis of tumor clonality. Adv Cancer Res. 2011; 112: 127–149.

      6. Joo S, Kim DK, Sim HJ, Lee GD, Hwang SK, Choi S, Kim HR, Kim YH, Park SI. Clinical results of sublobar resection versus lobectomy or more extensive resection for lung cancer patients with idiopathic pulmonary fibrosis. J Thorac Dis. 2016; 8(5): 977–984.

      7. E Watanabe N, Taniguchi H, Kondoh Y, Kimura T, Kataoka K, Nishiyama O, Kondo M, Hasegawa Y. Efficacy of chemotherapy for advanced non-small cell lung cancer with idiopathic pulmonary fibrosis. Respiration 2013; 85(4): 326–331.

      8. Hakyoung Kim, Hongryull Pyo, Jae Myoung Noh, Woojin Lee, Byoungsuk Park, Hye Yun Park and Hongseok Yoo. Preliminary result of definitive radiotherapy in patients with non-small cell lung cancer who have underlying idiopathic pulmonary fibrosis: comparison between X-ray and proton therapy. Radiat Oncol. 2019 Jan 28; 14(1):19.

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