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Olivier Leleu



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    Mini Oral session III (ID 65)

    • Event: ELCC 2019
    • Type: Mini Oral session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/12/2019, 17:45 - 18:45, Room C
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      43O - Baseline results from a French pilot study on lung cancer screening by CT scan: DEP KP80 (ID 317)

      17:45 - 18:45  |  Presenting Author(s): Olivier Leleu

      • Abstract
      • Presentation
      • Slides

      Background

      Lung cancer is the leading cause of cancer death worldwide. Two large randomized controlled trials (NLST,NELSON) founded a significant decrease in lung cancer mortality with an annual low dose CT screening among selected current or former smockers.While being now recommended in many countries, the French National Authority for Health claimed that conditions were not sufficient for implementation of such a screening program in France. The aims of our study were to assess the feasibility and effectiveness of a lung cancer screening pilot program with LD CT scan in a French department. We report here the results of the first screening round.

      a9ded1e5ce5d75814730bb4caaf49419 Methods

      DEP KP80 was a single-arm, prospective study started in May 2016 and ended in December 2018 in a French department (Somme). The inclusion criteria were those of the NLST study. An annual LD CT scan was scheduled and 2 rounds were planned. Our algorithms considered nodules<5mm as negative, nodules> 10mm as positive and recommended a 3-month CT with measurement of the doubling time for nodules between 5 and 10 mm . Smoking cessation was encouraged as part of the protocol. This study was managed by the departmental cancer screening agency (ADEMA80). All General Practitioners (GP), pulmonologists (PN) and radiologists from the department were solicited by mail to participate in this study. Subjects were selected by GP or PN who checked the inclusion criteria and precribed the CT scan.

      20c51b5f4e9aeb5334c90ff072e6f928 Results

      218 GP, 17 PN and 28 radiologists accepted to participate. Over a 2.5 years period, 1307 subjects were recruited. the participation rate was of 73% (949 scans were performed). Screening was negative in 733 cases (77%), positive in 54 (5.7%) and indeterminate in 162 (17%). The prevalence of a detected lung cancer was 2.5% : 24 cancers with 16 adenocarcinomas,3 squamous cell carcinomas, 1 carcinoid tumour, 2 small cell carcinomas 1 undetermined and 1 unknown. There were 2 carcinoma in situ (8%),13 Stage IA (54%), 3 Stage IIB (12%), 2 Stage IIIA (8%) and 4 Stage III B,C (17%). A surgery was performed in 20 of these patients (83%) and one patient underwent surgery for benign lesion.

      fd69c5cf902969e6fb71d043085ddee6 Conclusions

      This study demonstrates, at a regional level, the feasibility and effectiveness of an organized and structured lung cancer screening by LD CT scan in France.

      b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study

      O. Leleu.

      213f68309caaa4ccc14d5f99789640ad Funding

      La ligue contre le cancer Agence Régionale de Santé Picardie and AstraZeneca.

      682889d0a1d3b50267a69346a750433d Disclosure

      All other authors have declared no conflicts of interest.

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