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Keisuke Kirita

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    Lunch & Poster Display session (ID 58)

    • Event: ELCC 2019
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1
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      209P - Feasibility and utility of transbronchial cryobiopsy in primary lung cancer: Prospective, single arm study (ID 160)

      12:30 - 13:00  |  Presenting Author(s): Keisuke Kirita

      • Abstract


      Transbronchial forceps biopsy (FB) is the standard diagnostic tool for primary lung cancer. Recently, we need much amount of tissues for pathological diagnosis, mutational analysis and immunohistochemistry (IHC). The aim of this study was to prospectively evaluate safety, utility for diagnosis of primary lung cancer and biomarker analysis using cryoprobe, that was new transbronchial biopsy tool.

      a9ded1e5ce5d75814730bb4caaf49419 Methods

      A total of 128 patients with suspected of primary lung cancer were enrolled in this single arm trial and 121 patients were performed both transbronchial normal FB and transbronchial cryobiopsy (TBCB). We evaluated safety especially in bleeding and pneumothorax, diagnostic yield of malignancies, morphological diagnosis, size, tumor concentration of tissue samples and success rate of biomarker analysis.

      20c51b5f4e9aeb5334c90ff072e6f928 Results

      Total diagnostic yield of TBCB was 92% (111/121), in details, 97% (62/64) in central bronchial lesions and 86% (49/57) in peropheral lung lesions. TBCB samples were more useful for morphological classification (86% vs. 79%), and larger size (median size was 15mm2vs. 2mm2, p < 0.001) than FB samples. The ratio of containing malignant cells in each FFPE samples were higher in TBCB (84% (148/177)) than in FB (73% (285/391)). TBCB was more useful for mutational analysis and PD-L1 IHC. Severe bleeding (need to sprinkle hemostatic) was observed each 1 case and grade 3 lung infection (need hospitalization and IV antibiotics) occurred in 4 patients (3%). There was no case of pneumothorax.

      fd69c5cf902969e6fb71d043085ddee6 Conclusions

      TBCB is safe technique and useful for diagnosis of primary lung cancer. Furthermore, we could obtain more quantity and better quality of sample for diagnosis and biomarker analysis in comparison with conventional FB.

      b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study

      National Cancer Center Hospital.

      213f68309caaa4ccc14d5f99789640ad Funding

      Japan Agency for Medical Research and development (15ck106111h0002).

      682889d0a1d3b50267a69346a750433d Disclosure

      All authors have declared no conflicts of interest.