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Judith Büntzel

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    Lunch & Poster Display session (ID 58)

    • Event: ELCC 2019
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1
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      208P - Sarcopenia as prognostic factor in lung cancer patients: A systematic review and meta-analysis (ID 461)

      12:30 - 13:00  |  Presenting Author(s): Judith Büntzel

      • Abstract


      Sarcopenia describes the loss of skeletal muscle mass. While this condition is associated with a high mortality in cancer patients, its influence on survival is still underestimated. Here we investigate the impact of sarcopenia on the prognosis of lung cancer patients.

      a9ded1e5ce5d75814730bb4caaf49419 Methods

      A systematic research for articles was performed using the PubMed database, Cochrane Library, Biomed Central, Science Direct and by manual search. Articles published between January 2009 and May 2018 meeting the inclusion criteria were investigated. We used data of overall survival in sarcopenic patients from retrospective and prospective studies for assessing the death risk. Sarcopenia was assessed either by computer tomography, by dual-energy X-ray absorptiometry scan or by bioelectrical impedance analysis. We extracted hazard ratio estimates from univariate and multivariate Cox proportional hazards models for meta-analysis. This study was prospectively registered at PROSPERO (International prospective register of systematic reviews; ID: 105940).

      20c51b5f4e9aeb5334c90ff072e6f928 Results

      Fifteen studies were eligible for meta-analysis including a total of 2521 lung cancer patients (UICC I-IV). Univariate analysis revealed a twofold increased death risk in sarcopenic -compared non-sarcopenic- patients; multivariate analysis even yielded a significant, threefold elevated risk of death. This higher mortality is independent of tumour stage (UICC I-IIIA vs. IIIB-IV). The death risk reduces if muscle mass is increased.

      fd69c5cf902969e6fb71d043085ddee6 Conclusions

      Here we investigated sarcopenia as potential prognostic factor in lung cancer patients. Muscle loss is an independent risk factor for increased death risk in lung cancer patients independent of cancer stage. This argues for implementing screening for sarcopenia into cancer care.

      b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study

      The authors.

      213f68309caaa4ccc14d5f99789640ad Funding

      Ministery of Science and Culture of Lower Saxony (Niedersächsischen Ministerium für Wissenschaft und Kultur).

      682889d0a1d3b50267a69346a750433d Disclosure

      J. Bünzel: Scholarship of the “Göttinger Kolleg für Translationale Medizin”, funded by the Ministery of Science and Culture of Lower Saxony (Niedersächsischen Ministerium für Wissenschaft und Kultur). All other authors have declared no conflicts of interest.