Virtual Library

Start Your Search

Vibhay Pareek

Author of

  • +

    Lunch & Poster Display session (ID 58)

    • Event: ELCC 2019
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1
    • +

      191P - Assessment of toxicity and clinical outcomes with SBRT in lung metastases: A single institute experience (ID 449)

      12:30 - 13:00  |  Presenting Author(s): Vibhay Pareek

      • Abstract


      Stereotactic body radiation therapy (SBRT) can help deliver a high biologically equivalent dose to the tumor volume in a small number of fractions with a steep dose fallout on surrounding healthy tissues. A retrospective analysis was performed on patients treated for lung oligo-metastatic disease from various histopathologies.

      a9ded1e5ce5d75814730bb4caaf49419 Methods

      A total of 155 patients were retrospectively assessed who were diagnosed with lung metastases in various primary malignancies. Clinical outcomes in the form of local control (LC), overall survival (OS) and progression free survival (PFS) were assessed. Toxicity was scored according to CTCAE grading. Univariate analysis was performed to correlate various prognostic factors associated with the disease and grade of toxicities associated. Patients were followed up and assessed for late toxicities as per the institution protocol.

      20c51b5f4e9aeb5334c90ff072e6f928 Results

      The median follow up was 22 months. Colorectal carcinomas formed the major site of primary disease followed by sarcoma and renal cell carcinoma. LC at 1 and 2 years was 94 and 86% respectively. OS at 1 and 2 years was 90, 68.8% respectively. Both OS and L were impacted by the primary histopathology and also the presence of extrapulmonary disease present. PFS at 1 and 2 years was 87% and 62% respectively. Primary histopathology, presence of extrapulmonary disease and age showed a correlation with prognosis at univariate analysis. The treatment follow-up showed no significant late toxicities and Grade 3 and 4 toxicities were not seen in the cohort.

      fd69c5cf902969e6fb71d043085ddee6 Conclusions

      The study suggests the role of SBRT as a treatment option for oligometastases in the lung. However, the factors mostly influencing prognosis were the presence of extra-pulmonary disease and the number of lung lesions. With lower number of metastases to treat, the outcome is found to be better.

      b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study

      V. Pareek.

      213f68309caaa4ccc14d5f99789640ad Funding

      Has not received any funding.

      682889d0a1d3b50267a69346a750433d Disclosure

      The author has declared no conflicts of interest.