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Ante Marušić



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    Lunch & Poster Display session (ID 58)

    • Event: ELCC 2019
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1
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      136P - Correlation of molecular status and anatomic sites of metastases at diagnosis of EGFR positive non-small cell lung cancer (NSCLC): A single institution experience (ID 462)

      12:30 - 13:00  |  Author(s): Ante Marušić

      • Abstract

      Background

      A significant proportion of NSCLC patients carry mutations in the epidermal growth factor receptor (EGFR) kinase domain, in most cases with the presence of a deletion mutation in exon 19 or L858R point mutation. The aim of our analysis was to examine the patterns of metastatic spread in IV stage nsclc and whether it varies by EGFR mutation status.

      a9ded1e5ce5d75814730bb4caaf49419 Methods

      All patients (pts) with stage IV NSCLC from 2014-2017, without a recent history of cancer, were diagnosed at our department in which anatomic sites of metastasis, before initial treatment, were recorded. Tumor tissues were further processed, and data on molecular testing (EGFR; ex19, ex 20, ex21 L858R) were extracted. Correlation between molecular status and anatomic sites of mets was assessed.

      20c51b5f4e9aeb5334c90ff072e6f928 Results

      We reviewed 206 pts with stage IV NSCLC, EGFR positive. Further molecular analysis: Ex 19 (n = 118 + 57.2%), Ex 20 ( n = 20 + 9.7%) , Ex 21 L 858R (n = 69; 33.4%). Most frequent mets sites were bone (28.2%), lung (27.9%), brain (22.8%) and supraclavicular lmph (18.2%). Pts with Ex20 had more brain mets (38.9% ) than pts with ex21 (7%), for ex 20 no significant result. Statistic significance was Ex20 with lymp supraclavicular (p = 0.006), Ex20 with effusion pericardi (p = 0.021). Interesting Ex21 L858R with meta hepatis (p = 0.044) and Ex19with meta hepatis (p = 0.083).

      fd69c5cf902969e6fb71d043085ddee6 Conclusions

      Molecular status of NSCLC is associated with biological behavior. Most frequent meta site were bone, at diagnosis 39.2% of EGFR + pts. Because of better prognosis for EGFR+ pts screening and prevention of skeletal-related events in NSCLC pts is reasonable.

      b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study

      Kristina Krpina.

      213f68309caaa4ccc14d5f99789640ad Funding

      Has not received any funding.

      682889d0a1d3b50267a69346a750433d Disclosure

      All authors have declared no conflicts of interest.

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