Author of

• 28971

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  Lunch & Poster Display session (ID 58)

  • Event: ELCC 2019
  • Type: Poster Display session
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1

  • 29045

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    92P - A prospective study on the association of dose-volume histogram parameters with oesophagitis, radiation pneumonitis, radiation induced pulmonary fibrosis after receiving chemoradiation for NSCLC (ID 241)

    12:30 - 13:00  |  Presenting Author(s): SAIKAT Bhowal
    • Abstract

    Background
    

    The aim of this study was to assess the relationship between pulmonary V30, age, gender, smoking history, tumor location & incidence, grade of oesophagitis, radiation pneumonitis (RP) and radiation induced pulmonary fibrosis (RIPF) (within radiotherapy portals) in NSCLC patients treated with chemoradiation.

    a9ded1e5ce5d75814730bb4caaf49419 Methods
    

    A hospital-based prospective study of 64 NSCLC patients treated (between November 2017–2018) with chemoradiation (paclitaxel & carboplatin + total 60 Gy in 30# i.e. 2Gy once daily) was conducted. Relationship between pulmonary V30, age, gender, smoking history, tumor location & incidence, grades of oesophagitis, RP, RIPF (HRCT confirmed) with a median follow up of 7 months was analysed using Spearman's rank correlation coefficient in SPSS software (multivariate analysis). Kruskal Wallis test was used to test significance. Ethical clearance was obtained from the local ethics committee.

    20c51b5f4e9aeb5334c90ff072e6f928 Results
    

    1) Oesophagitis of grade 0,1,2,3,4 was diagnosed in 23,30,8,2&0 patients respectively. Corresponding mean V30 values were 33.8%,34.5%,37.2%,39.6& 41.2% 2) RP of grade 0,1,2,3,4 was detected in 18,19,24,2&1 patients respectively. Corresponding mean V30 values were 21.3%, 22.4%,26.8%,30.0%& 36.2%. 3) RIPF of grade 0,1,2,3,4 was detected in 32,26,8,0&0 patients respectively. Corresponding mean V30 values were 31.2%,34.4%,35.9%,38% &38.6%. 4) Significant correlation was detected between V30≥30%& incidence & grade 2 oesophagitis (p = 0.02, r = 0.86), grade 2 radiation pneumonitis (p = 0.001, r = 0.74), grade 1 RIPF (p = 0.01, r = 0.88). 5) Increasing age (p = 0.03), smoking history (p = 0.04), tumor location i.e. upper vs middle/lower lobe (p = 0.02) had a significant correlation with incidence and grades of oesophagitis, RP, RIPF.

    fd69c5cf902969e6fb71d043085ddee6 Conclusions
    

    Hence, the incidence and grades of oesophagitis, RP, RIPF are significantly related to lung V30≥30%, age, smoking history, and tumor location.

    b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study
    

    Institute of Post Graduate Medical Education & Research & SSKM Hospital, Kolkata.

    213f68309caaa4ccc14d5f99789640ad Funding
    

    Institute of post graduate medical education & research & SSKM Hospital, Kolkata.

    682889d0a1d3b50267a69346a750433d Disclosure
    

    All authors have declared no conflicts of interest.

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