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H S Kumar



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    Lunch & Poster Display session (ID 58)

    • Event: ELCC 2019
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1
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      65P - Experience of prophylactic cranial irradiation in extensive stage small cell lung cancer at a regional cancer center in India (ID 536)

      12:30 - 13:00  |  Author(s): H S Kumar

      • Abstract

      Background

      We conducted this randomized trial at our center to assess benefits of prophylactic cranial irradiation (PCI) in cases of extensive stage small cell lung cancer (eSCLC), who showed complete or partial response to 4 cycles of cisplatin and etoposide chemotherapy-based regime.

      a9ded1e5ce5d75814730bb4caaf49419 Methods

      For the study, 71 patients of histology proven SCLC with extensive stage (with no symptomatic and radiological brain metastasis) on clinico-radiological examination were randomized into two arms (Arm A and Arm B). Patients in Arm A were treated with PCI whilw those in Arm B were kept on observation, patient in both arms were followed for 1 year. Primary endpoint of the study was to assess the time of onset of symptomatic brain metastasis in both arms. Computer Tomography (CT scan) or Magnetic Resonance Imaging (MRI) was performed in patients who had any symptom suggestive of brain metastasis.

      20c51b5f4e9aeb5334c90ff072e6f928 Results

      Patients in both arms (36 in Arm A and 35 in Arm B) were comparable for baseline characteristics. Patients in Arm A had significantly low risk of symptomatic brain metastasis then Arm B (p value = <0.005). The risk of brain metastasis in Arm A was 19.4% and in Arm B it was 51.4%. Mean duration for freedom from symptomatic brain metastasis in Arm A was 8.36 months while it was 4.49 months for Arm B. Overall 1 year median survival rate in Arm A was significantly higher in Arm A then Arm B (8 months vs 4 months). Patients in Arm A had higher toxicities, but they were mostly manageable and were not associated with poor quality of life.

      fd69c5cf902969e6fb71d043085ddee6 Conclusions

      PCI is associated with significantly low risk of symptomatic brain metastasis and higher overall survival without affecting quality of life in eSCLC.

      b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study

      Aacharya Tulsi Regional Cancer Treatment and Research Center, Bikaner.

      213f68309caaa4ccc14d5f99789640ad Funding

      Has not received any funding.

      682889d0a1d3b50267a69346a750433d Disclosure

      All authors have declared no conflicts of interest.

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