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Lynda M McSorley

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    Lunch & Poster Display session (ID 58)

    • Event: ELCC 2019
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1
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      64P - Timing of treatment with concurrent chemoradiotherapy (CRT) and impact on progression free survival (PFS) in limited stage small cell lung cancer (LSSCLC) (ID 601)

      12:30 - 13:00  |  Presenting Author(s): Lynda M McSorley

      • Abstract


      SCLC is an aggressive cancer subtype, with early metastatic spread and poor prognosis. We review Irish patient outcomes, outside of a clinical trial setting, to determine if patients who commenced radiotherapy (RT) within 30days of chemotherapy (CT) had a longer PFS.

      a9ded1e5ce5d75814730bb4caaf49419 Methods

      SCLC cases diagnosed between 2006-2016 were identified from a prospectively maintained lung cancer registry at a tertiary referral centre. Electronic patient records, paper charts, and pathology reports were reviewed to extract relevant data. In order to detect a statistical difference between the two groups with 95% confidence interval and a 5% margin of error, a sample size of 125 patients with SCLC was needed, and a sample size of 56 with LSSCLC. A two-sided t-test was used where data was normally distributed. A p value of < 0.05 was accepted. Kaplan-Meier analysis was used to assess progression free survival and a Mann-Whitney test to assess differences between groups.

      20c51b5f4e9aeb5334c90ff072e6f928 Results

      265 patients identified, 70 with LSSCLC, 44 had concurrent treatment. Median time to starting CT was 20 days (95%CI; 15.8-24.2days). The median time between diagnosis and CT was 28days, from CT to RT was 28.5 days. 21 patients started RT within 30 days of commencing CT; median time 19days. 19 patients started RT more than 30 days post CT; median time 67days. Median time from diagnosis to CT was 12days in this group. Median PFS where the time from day1 CT to day1 of RT was less than 30days was 12.1months. For patients where the treatment interval was greater than 30 days, median PFS was 10.6months. Using a non-parametric Mann-Whitney test to evaluate the median PFS produced a U value of 127, and a P-value of 0.41.

      fd69c5cf902969e6fb71d043085ddee6 Conclusions

      This study reports real-world outcomes in patients with LSSCLC over a 10-year period. Although not reaching statistical significance there is a numerical difference in PFS favouring shorter time to combination CRT. We have also identified areas where there is room to improve our practice. Further attention will focus on strategies to reduce both the interval between histological diagnosis and commencing CT, and the interval between CT and RT in this setting. A study expansion is planned.

      b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study

      The authors.

      213f68309caaa4ccc14d5f99789640ad Funding

      Has not received any funding.

      682889d0a1d3b50267a69346a750433d Disclosure

      All authors have declared no conflicts of interest.