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Jing Yu

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    Lunch & Poster Display session (ID 58)

    • Event: ELCC 2019
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1
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      61P - Value of post-radiotherapy for limited stage small cell lung cancer on basis of a prognostic scoring model (ID 292)

      12:30 - 13:00  |  Presenting Author(s): Jing Yu

      • Abstract
      • Slides


      Small cell lung carcinoma (SCLC) rarely underwent surgical treatment. The aim of the study was to investigate the value of postoperative radiotherapy for limited stage small cell lung cancer based on a prognostic scoring model.

      a9ded1e5ce5d75814730bb4caaf49419 Methods

      We searched the Surveillance, Epidemiology, and End Results (SEER) database for all cases of limited stage SCLC treated by surgical resection and chemotherapy between 2004-2014. A prognostic scoring model was built to evaluate the prognostic value of postoperative radiotherapy on the basis of a Cox proportional hazards model. Overall survival (OS) and cancer-specific survival (CSS) was compared in the different risk groups.

      20c51b5f4e9aeb5334c90ff072e6f928 Results

      Multivariable analysis of the association between clinical variables and overall survival (N = 767)

      VariablesHR (95%CI)P
      Age (>65 vs ≤ 65 y)1.35 (1.17-1.57)<0.001
      Race (White vs non-white)1.18 (0.90-1.55)0.238
      Sex (Male vs Female)1.33 (1.15-1.54)<0.001
      Grade (Poor/ undifferentiated vs Well/Moderately/NOS0.99 (0.86-1.15)0.922
      Lymph Node Stage (N+ vs N-)1.36 (1.17-1.58)0.001
      T stage (T3/4 vs T1/2)1.31 (1.08-1.58)0.005
      Laterality (Left vs Right vs NOS)1.04 (0.91-1.19)0.55
      Primary lobe (Main bronchus vs Upper vs Middle vs Lower vs Overlapping lesion of lung or NOS)1.01 (0.94-1.09)0.717

      fd69c5cf902969e6fb71d043085ddee6 Conclusions

      On the basis of the prognostic scoring model, postoperative-radiotherapy in addition to surgery provides better outcomes than surgery alone for limited stage SCLC in high risk group. Prospective studies are needed to validate these results.

      b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study

      Jing Yu.

      213f68309caaa4ccc14d5f99789640ad Funding

      Has not received any funding.

      682889d0a1d3b50267a69346a750433d Disclosure

      All authors have declared no conflicts of interest.


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