Author of

• 28971

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  Lunch & Poster Display session (ID 58)

  • Event: ELCC 2019
  • Type: Poster Display session
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1

  • 29013

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    48P - Education and lung cancer: A Mendelian randomisation study (ID 189)

    12:30 - 13:00  |  Author(s): Jiaqing Liu
    • Abstract
    • Slides

    Background
    

    Education has been shown to be inversely associated with the incidence of lung cancer at several conventional observational studies. However, this association may be biased owing to the methodological limitations of traditional observational study-confounding, reverse causation, and measurement error. Therefore, we aimed to investigate whether more years spent in education is causally associated with risk of lung cancer through a two sample mendelian randomisation study.

    a9ded1e5ce5d75814730bb4caaf49419 Methods
    

    The main analysis used publicly available genetic summary data from two large consortiums (International Lung Cancer Consortium (ILCCO) and Social Science Genetic Association Consortium (SSGAC)). Genetic variants used as instrumental variables for lung cancer and years of education were derived from two large genome wide association studies: ILCCO and SSGAC, respectively. Finally, genetic data from three additional consortia (TAG, GLGC, GIANT) were analyzed to investigate whether longer education can causally alter the common lung cancer risk factors. The exposure was the genetic predisposition to higher levels of education, measured by 73 SNPs from SSGAC. The primary outcome was the risk of lung cancer (11348 events in ILCCO). Secondary outcomes based on different histologic subtypes were also examined.

    20c51b5f4e9aeb5334c90ff072e6f928 Results
    

    Genetic predisposition towards 3.6 years of additional education was associated with a 52% lower risk of lung (odds ratio 0.48, 95% confidence interval 0.34 to 0.66; p = 1.02 × 10−5). Sensitivity analyses were consistent with a causal interpretation in which major bias from genetic pleiotropy was unlikely. The Mendelian randomisation assumptions did not seem to be violated. Genetic predisposition towards longer education was additionally associated with less smoking, lower body mass index, and a favorable blood lipid profile. Table: 48P

    Mendelian randomisation estimates of the associations between education attainment and risk of lung cancer overall and histologic types

    Outcome	IVW method	MR-Egger	Weighted median method
    OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
    Lung cancer overall	0.48 (0.34-0.66)	1.02e-05*	0.61 (0.12-3.17)	0.56	0.52 (0.35-0.77)	1.08e-03*
    Adenocarcinoma	0.64 (0.41-1.00)	4.97e-02*	0.89 (0.09-8.48)	0.92	0.59 (0.32-1.08)	8.94e-02
    Squamous cell carcinoma	0.41 (0.27-0.62)	2.57e-05*	0.32 (0.04-2.63)	0.29	0.55 (0.30-1.01)	5.24e-02

    *

    : P value < 0.05; IVW: inverse-variance weighted; OR: odds ratio; CI: confidence interval.

    fd69c5cf902969e6fb71d043085ddee6 Conclusions
    

    Our present mendelian randomisation study provided strong evidence to support that higher education attainment plays a causal role in lowering the risk of lung cancer. Furthermore, more work is needed to elucidate the potential mechanisms which mediate the association between education and lung cancer.

    b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study
    

    The authors.

    213f68309caaa4ccc14d5f99789640ad Funding
    

    National Key R&D Program of China (Grant No. 2016YFC0905500, 2016YFC0905503).

    682889d0a1d3b50267a69346a750433d Disclosure
    

    All authors have declared no conflicts of interest.

    cffcb1a185b2d7d5c44e9dc785b6bb25

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