Author of

• 28971

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  Lunch & Poster Display session (ID 58)

  • Event: ELCC 2019
  • Type: Poster Display session
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1

  • 29004

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    37P - Genetic variation of lymphotoxin beta receptor (LTβR) rs10849448 (A/G) is associated with risk for lung cancer and metastatic spread to adrenals (ID 526)

    12:30 - 13:00  |  Author(s): Melpomeni Kalofonou
    • Abstract

    Background
    

    During the last years there is an expansion of our knowledge in lung cancer immunology. In addition, there is a growing number of studies on the role of lymphotoxin beta receptor (LTβR), a member of the tumor necrosis factor (TNF) family, which plays an important role in lymphoid system formation and homeostasis as well as in immune system regulation mainly through NF-κB signaling. The aim of the current study was to investigate the clinical relevance of LTβR single nucleotide polymorphism (SNP) rs10849448 (A/G) with the susceptibility to NSCLC, the clinicopathological parameters, the relapse and the survival rates of NSCLC patients, as well as with the protein expression of LTβR.

    a9ded1e5ce5d75814730bb4caaf49419 Methods
    

    LTβR SNP was genotyped in 268 randomly selected NSCLC patients and 279 age- and gender-matched healthy donors. Immunohistochemical analysis for LTβR was performed on 127 NSCLC tumors. The studied cohort was under observation during a five-year period.

    20c51b5f4e9aeb5334c90ff072e6f928 Results
    

    Genotype frequencies of rs10849448 (AA, AG, and GG) varied between healthy controls and patients, but the difference did not reach statistical significance (P = 0.054). AA homozygotes were found to have lower risk for NSCLC compared to G allele carriers in univariate as well as in multivariate analysis (both P = 0.016). Moreover, rs10849448 was associated with development of metastases with A allele carriers developing less often metastatic disease in adrenals (P = 0.013). Interestingly, rs10849448 was related to membranous LTβR protein expression (P = 0.035) in malignant cells, with AA homozygotes being associated with higher protein levels.

    fd69c5cf902969e6fb71d043085ddee6 Conclusions
    

    The present findings suggest that the investigated SNP rs10849448 may be associated with NSCLC initiation as well as with the development of metastatic disease. More association and functional studies are needed in order to further clarify it’s role in NSCLC.

    b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study
    

    H. Kalofonos.

    213f68309caaa4ccc14d5f99789640ad Funding
    

    This research was co-funded by the Hellenic Society of Medical Oncology (HeSMO) through a research funding program.

    682889d0a1d3b50267a69346a750433d Disclosure
    

    All authors have declared no conflicts of interest.

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