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YInchen Shen

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    Lunch & Poster Display session (ID 58)

    • Event: ELCC 2019
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/11/2019, 12:30 - 13:00, Hall 1
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      35P - Clinicopathological characteristics with genetic profiling and prognostic analysis of primary lymphoepithelioma-like carcinoma in Chinese south-eastern population (ID 275)

      12:30 - 13:00  |  Presenting Author(s): YInchen Shen

      • Abstract
      • Slides


      Primary lymphoepithelioma-like carcinoma (LELC) is a rare form of lung cancer, since genetic alternations participate in the carcinogenesis in lung cancer, whether critical driver genes such as ROS1 fusion, anaplastic lymphoma kinase (ALK) rearrangement and epidermal growth factor receptor (EGFR) mutation play roles in LELC remains unclear.

      a9ded1e5ce5d75814730bb4caaf49419 Methods

      We collected a total of 30 LELC samples for genetic and prognosis analysis retrospectively in ShangHai Chest Hospital, EGFR gene mutation, ALK rearrangement and ROS1 fusion status were extracted from digital database. Clinicopathological characteristics with genetic profiling and survival were analyzed.

      20c51b5f4e9aeb5334c90ff072e6f928 Results

      All samples appeared negative for genes (EGFR, ALK and ROS1) alternations detection. Female gender acted as an independently prognostic factor in poorer disease-free survival (DFS) (P = 0.034), and tumors locate in the left lobe associate with worse DFS in univariate analysis (significant trend, P = 0.051), moreover, serum positive NSE level also indicate a shorter DFS after adjustment (significant trend, P = 0.057). Most of LELC are diagnosed at early stage, with 93.3% (27/30) patients obtained the opportunities for surgery.

      fd69c5cf902969e6fb71d043085ddee6 Conclusions

      Since no classical genetic alternations appeared in present study, more investigations of other genes distributions should be explored in the future for better understanding of this rare subtype of lung cancer. Serum positive NSE level seemed to be a prognostic biomarker for DFS in LELC patients.

      b651e8a99c4375feb982b7c2cad376e9 Legal entity responsible for the study

      The authors.

      213f68309caaa4ccc14d5f99789640ad Funding

      Has not received any funding.

      682889d0a1d3b50267a69346a750433d Disclosure

      All authors have declared no conflicts of interest.


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