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Poster Session (ID 8)
- Event: ACLC 2018
- Type: Poster Session
- Presentations: 1
- Coordinates: 11/07/2018, 00:00 - 00:00, Poster Hall
P093 - DNA Methylation in CTC And ctDNA is A Promising Marker for Early Detection of Lung Cancer Metastasis (ID 183)
00:00 - 00:00 | Author(s): X. Qiu
Lung cancer is the leading cause of cancer-related death worldwide and metastatic dissemination of lung cancer cells represents a significant clinical obstacle to cure the the disease. Aberrant DNA methylation represses gene expression and correlates with cell proliferation, angiogenesis, invasion and metastasis. Many DNA methylation markers have already been used in the early detection of lung cancer. The role of DNA methylation in lung cancer metastasis remains poorly understood and no satisfied marker predicting metastasis were found up to date. We will try to screen out usable methylation markers to improve our diagnosis for metastasis in lung cancer.
Scientific literature databases were exhaustively searched to retrieve published studies relevant to DNA methylation and NSCLC metastasis. Retrieved studies published in English and Chinese languages were screened according to the stringent predefined inclusion and exclusion criteria, and high quality studies were selected for further analysis. Genes were screened and sorted for further validation.
A total of 45 published studies were selected in the present analysis. 23 genes or microRNAs were studied in the relationship between methylation and tumor metastasis. The genes include metastatic genes, metastasis suppressor genes , EMT-related genes, microRNAs and noncoding RNA. The methylation rate of these genes and tumor metastasis were studied. Genes with intensive research include P16, Rassf1, DAPK, HOXA5, SOX9, MALAT1 and microRNAs such as mir-182, mir-139. mir-224. No further studies were regarded in the prediction value of these markers in serum and CTC in lung cancer metastasis. These markers might be validated in metastasis prediction in further studies.
Our analysis results reveal that methylation might be associated with tumor metastasis and poor prognosis in NSCLC patients, and might be good markers in liquid biopsy for early detection of lung cancer metastasis.