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F. Xu

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    Poster Session (ID 8)

    • Event: ACLC 2018
    • Type: Poster Session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 11/07/2018, 00:00 - 00:00, Poster Hall
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      P042 - LincRNA00494 Suppresses Non-Small Cell Lung Cancer Cell Proliferation by Regulating SRCIN1 Expression in A ceRNA Manner (ID 182)

      00:00 - 00:00  |  Author(s): F. Xu

      • Abstract

      Lung cancer has been recognized as the leading cause of cancer-related deaths throughout the world . Due to failing early diagnosis and severe chemotherapy response, the 5-year survival rate of lung cancer has been staggering at about 15% . Therefore, searching for new biomarkers for metastatic progression of non-small cell lung cancer (NSCLC) is urgent. Recent studies have demonstrated the association between long non-coding RNA (LncRNA) and multiple cancer types. LincRNA00494, a novel long intergenic non-protein coding gene, its function has not been fully expounded. In the present study, we found that LincRNA00494 was down-regulated in non-small cell lung cancer tissue compared with the corresponding adjacent non-tumor tissue. Our findings might reveal the underlying mechanism by which LincRNA00494 aberrant expression conferred NSCLC tumorigenesis.

      We compared the expression level of LINCRNA00494 by RT-PCR in 163 patients with non-small cell lung cancer with the tumor tissue and the normal tissue of distant cancer. We compared the association between LINCRNA00494 and SRCIN1 mRNA in tumor tissues by RT-PCR. Plasmid knockdown and overexpression of LINCRNA00494 were used to compare the effects of changes in LINCRNA00494 expression on SRCIN1 mRNA. To verify the role of miR-150-3p in NSCLC cells, we cloned the 3