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R. Doebele

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    Best abstracts selected from submissions 5 (ID 6)

    • Event: ACLC 2018
    • Type: Oral Session
    • Track:
    • Presentations: 1
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      OA09 - Preliminary Clinical Activity of Repotrectinib (TPX-0005) in Advanced ROS1 Fusion-Positive Non-Small Cell Lung Cancer (ID 178)

      16:20 - 17:00  |  Author(s): R. Doebele

      • Abstract
      • Slides

      Patients (pts) with ROS1+ advanced NSCLC can be effectively treated with ROS1 tyrosine kinase inhibitors (TKIs). However, acquired resistance inevitably develops, resulting in disease relapse. Repotrectinib is a potent next-generation ROS1/TRK/ALK TKI, which inhibits ROS1 with a >90-fold greater potency (IC50 <0.2 nM) than crizotinib. Preclinical studies demonstrate robust activity of repotrectinib against all known clinical ROS1 resistance mutations, including ROS1 G2032R resistance solvent-front mutation.

      In this phase I study (NCT03093116), eligible adult pts with TKI-na

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