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Poster Session (ID 8)
- Event: ACLC 2018
- Type: Poster Session
- Presentations: 1
- Coordinates: 11/07/2018, 00:00 - 00:00, Poster Hall
P039 - Clinical Characteristics and Survival of Patients with Lymphoepithelioma-Like Carcinoma in Lung and Bronchus and Other Sites (ID 159)
00:00 - 00:00 | Author(s): D. Lu
Lymphoepithelioma-like carcinoma (LELC), an unusual histological type of malignancy, occurs in almost all anatomic sites of body including lung and bronchus. Although with strong ties to Epstein-Barr virus infection, LELC at different sites has distinct clinical characteristics. Because of the rarity, it is however largely unclear whether LELC at different sites would lead to different prognosis, independent of clinical characteristics.
Based on the population-based cancer cohort from the Surveillance, Epidemiology, and End Results database (SEER), we identified all LELC patients from year 1973 to 2015. According to tumor sites, we classified LELC patients into lung and bronchus, nasopharynx, and another eight most common sites. We studied overall survival as the primary outcome, while tumor characteristics as the secondary outcome.
In total, we identified 2079 LELC patients, of which 86 (4%) were positioned at lung and bronchus and 1208 (58%) at nasopharynx (Figure 1A). Patients with lung and bronchus LELC were older at diagnosis and with more advanced stage, as compared to nasopharyngeal LELC. The 5-year overall survival rates of LELC of lung and bronchus as well as nasopharynx were 35.8% and 59.5% in patients with localized stage (Figure 1B), while 35.1% and 55.5% in patients with regional stage (Figure 1C), respectively. After controlling for tumor characteristics and treatment modes, patients with lung and bronchus LELC were associated with increased risk of overall mortality as compared with LELC of nasopharynx (HR 1.72, 95% CI 1.03 to 2.88).
The demographics and clinical features of LELC greatly differ by organ of origin. Site may be an important predictor for survival in patients of LELC. Compared with LELC of nasopharynx, pulmonary LELC is associated with worse prognosis, independent of common prognostic factors.