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Poster Session (ID 8)
- Event: ACLC 2018
- Type: Poster Session
- Presentations: 1
- Coordinates: 11/07/2018, 00:00 - 00:00, Poster Hall
P084 - Musashi-2 Expression Is an (ID 148)
00:00 - 00:00 | Author(s): T. Wang
Most patients with non-small cell lung cancer (NSCLC) would have local or distant metastases at the time of diagnosis and lose the chance of cure. Currently, there is no reliable biomarker to predict the lymph node metastasis and prognosis of NSCLC. As an RNA-binding protein, the Musashi-2 gene blocks translation by binding to mRNA non-translated region and plays an important role in regulating biological procedures of cell. Existing studies have suggested that Musashi-2 protein associates with the development and poor prognosis of various solid tumors and was reported overexpressed in lung cancer tissue compared with normal lung tissue. Our study aimed to assess the role of Musashi-2 expression in lymph node metastasis and postoperative survival.
In this present study, immunohistochemistry (IHC) was performed to characterize expression of Musashi-2 protein in NSCLC patients who underwent radical surgeries in our hospital between 2008 and 2013. The expression of Musashi-2 protein in human lung cancer tissues, paracancerous tissues, and metastatic lymph nodes was detected by IHC. The relationship between Musashi-2 protein expression and clinicopathological features, including gender, age, smoking history, pathological type, tumor size, TNM classification, lymph nodes metastasis, and postoperative survival, was analyzed. Kaplan-meier survival analysis and multivariate analysis were used to evaluate the significance of Musashi-2 overexpression as an independent adverse prognostic factor for NSCLC patients received surgery.
The results revealed that Musashi-2 protein expression was significantly lower in adjacent non-tumor tissues than that in primary lung cancer tissues (P?0.001). The Musashi-2 protein expression was lower in primary lung cancer tissues than that in metastatic lymph nodes (P?0.001). Chi-square test showed that Musashi-2 protein expression was correlated to tumor size (P?0.05), pathological type (P?0.05), tumor stage (P?0.001), and lymph node metastasis (P?0.001), but not to gender, age, smoking history or tumor grade. Kaplan-Meier survival analysis indicated an association of high Musashi-2 protein overexpression with worse postoperative survival in patients with NSCLC (P?0.001). Multivariate COX regression analysis furtherly confirmed that Musashi-2 protein overexpression is an independent predictor for postoperative survival (P?0.001).
Therefore, Musashi-2 protein overexpression significantly correlates with lymph node metastasis and predicts poorer postoperative survival of NSCLC patients. It may serve as a novel prognostic marker in these patients.