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K. Ma



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    Poster Session (ID 8)

    • Event: ACLC 2018
    • Type: Poster Session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 11/07/2018, 00:00 - 00:00, Poster Hall
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      P114 - Whole-Exome Sequencing (ID 118)

      00:00 - 00:00  |  Author(s): K. Ma

      • Abstract

      Background:
      Lung adenocarcinoma is an evolutional disease, which includes different stages such as atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) , and invasive adenocarcinoma (IA) ,which all can occur independently with each other. However, whether these primary tumors exist synchronous or successively in just one individual. What is the major factor to drive a focus developing from AAH (benigh) to MIA or IA(malignant). In this study, we reported a case with AAH, MIA, and IA to understand and recognize this kind of disease, and to explore the gene heterogeneities among these focuses.


      Method:
      XXX, female, 50 years old?non-smoker,whose chest CT suggested two nodules in the right upper lobe, sized 1 cm and 0.5 cm, respectively .Surgical resection in the upper lobe of the right lung was performed for her. Postoperative pathology confirmed that these two nodules were IA and MIA, respectively. Besides those, a third more nodule, which was AAH was found in the deeper resectional lung tissue which had not been found in the chest CT scan. We then performed whole-exome sequencing (WES) to analyze the details of gene information.


      Results:
      Sequencing data showed that there was no obvious overlap among these three nodules, we listes the major gene information in Figure 1. We found that EGFR mutation was just observed in the nodule with IA, but not in MIA or AAH. figure 1.jpg


      Conclusion:
      AAH, MIA, and IA are different evolutional stages of lung adenocarcinoma. Different gene information existing in these different pathologies made them highly heterogenous. EGFR should be the major driver gene which could be observed just in IA, but not in the earlier evolutional stage. More sequencing data is needed to verify our findings.