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J. Zhen

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    Poster Session (ID 8)

    • Event: ACLC 2018
    • Type: Poster Session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 11/07/2018, 00:00 - 00:00, Poster Hall
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      P049 - Neurocognitive Functions Before Radiotherapy for Brain Metastasis from Lung Cancer: An Analysis of 74 Cases (ID 97)

      00:00 - 00:00  |  Author(s): J. Zhen

      • Abstract

      To assess the baseline neurocognitive functions in patients with brain metastasis from lung cancer before receiving radiotherapy, and determine the risk factors for neurocognitive function impairment.

      The clinical data of patients suffering from brain metastasis from lung cancer who were admitted to Guangdong Sanjiu Brain Hospital from January 2017 to December 2017 were retrospectively analyzed. At 1-2 weeks before radiotherapy for brain metastasis, several scales were used to assess the neurocognitive functions in the 74 patients. Psychometricians assessed and divided the the neurocognitive functions into 4 levels, namely normal, mild impairment, moderate impairment and severe impairment. All analyses were performed using the statistical package R, to analyze the relationships between cognitive assessment results and clinical characteristics, and Kappa test was used to analyze the consistency of physical examination and cognitive scales for assessing the neurocognitive functions in patients. Finally, the related factors were analyzed with univariate and multivariate analysis.

      Clinical physical examination showed that there were 21 cases of cognitive decline (28.4%) and 53 cases of normal cognition (71.6%), while the results of cognitive scales revealed that there were 6 cases of normal cognition (8.1%), 26 cases of mild impairment (35.1%), 2 cases of moderate impairment (2.7%) and 40 cases of severe impairment (54.1%). The result of Kappa test showed Kappa<0.4, indicating that the differences between cognitive scale results and physical examination were significant. The univariate analysis on the factors related to neurocognitive function impairment revealed that the risk factors that may affect the degree of neurocognitive function impairment included age, KPS score, GPA score, RPA class and the number of metastatic tumors; and the multivariate analysis showed that age and RPA class>2 were the independent risk factors for neurocognitive function impairment.

      Patients with brain metastasis from lung cancer have various degrees of neurocognitive function impairment before receiving radiotherapy. Compared with clinical physical examination, the cognitive scales can greatly improve the detection rate of neurocognitive function impairment. Age and RPA class>2 are considered as independent risk factors for neurocognitive function impairment.