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J. Chen

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    Poster Session (ID 8)

    • Event: ACLC 2018
    • Type: Poster Session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 11/07/2018, 00:00 - 00:00, Poster Hall
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      P069 - HOTAIR, A Long Non-Coding RNA, Is a Marker of Abnormal Cell Cycle Regulation in Lung Cancer (ID 68)

      00:00 - 00:00  |  Author(s): J. Chen

      • Abstract

      The dis-regulation of cell cycle is an obvious marker of tumors including lung cancer. Recently, the study of cell cycle inhibitor has made great progress in lung cancer. While a question, what kinds of patients could use cell cycle inhibitor, has plagued us. So seeking an accurate and convenient marker for the abnormal cell cycle in lung cancer is very important.

      MTT, EdU, Transwell, ChIRP, Western-blot, luciferase reporter assay, Orthotopic nude mouse model, Immunohistochemistry

      In the present research we had showed lnc-RNA HOTAIR is an optimal indicator of cell cycle dis-regulation in lung cancer. HOTAIR specific expression in lung primary tumor sample by the analysis of TCGA public database and 67 pairs of patients