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Z. Yu

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    Poster Session (ID 8)

    • Event: ACLC 2018
    • Type: Poster Session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 11/07/2018, 00:00 - 00:00, Poster Hall
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      P120 - How to Become Exsomes As Messengers and Sentinels to Influence Lung Cancer Growing? (ID 44)

      00:00 - 00:00  |  Author(s): Z. Yu

      • Abstract

      How to become Exsomes as messengers and sentinels to influence lung cancer growing? Zhang Yu1, Chen Chang2 1. The Thoracic Surgery Department in The First Hospital of Lanzhou University, Lanzhou city, China; 2. The Shanghai Pulmonary Hospital of Tongji University, Shanghai, China. Email: *[email protected]* Tel: +86-15095319196 Abstract: [Background] Exsomes are special capsules including proteins, DNA, RNA, etc. They have great important role in Cell Growth, Cell Invasion, Cell Differentiation. How to transfer the messages to tumor cells each other and influence tumor cells invasion is hard question.

      [Methods] First, exosomes involved in the division and proliferation of cancer cells were detected in lung cancer cell lines. Second, the animal model of lung cancer was made, and tumor specimens were regularly cut to detect the quantitative and qualitative changes of exosomes in tumor cells, so as to analyze the changes of exosomes in tumor growth. Thirdly, specific exosomes were calibrated and tracked to inhibit the secretion of specific exosomes and observe the division and growth of tumor cells.

      [Results] The secretion of exosomes significantly affected the pathological and physiological mechanism of lung cancer cell division, differentiation, growth and invasion.

      [Conclusion] Exosomes are important messengers that affect tumor cells, but how the messengers send signals, how they affect the mechanism of the tumor cells, and how to turn the "messenger" into a "sentinel" that monitors tumors is a long way off.